ZFIN ID: ZDB-GENE-001103-1
Gene Name: SRY-box transcription factor 9a
Gene Symbol: sox9a    Nomenclature History

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Previous Names: jef (1), jellyfish, wu:fj17b12, zgc:111921

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Exhibits chromatin binding activity. Involved in cartilage morphogenesis; embryonic morphogenesis; and glial cell differentiation. Localizes to cytoplasm. Is expressed in several structures, including brain; ectoderm; head; reproductive system; and skeletal system. Human ortholog(s) of this gene implicated in 46,XX sex reversal 2; 46,XY sex reversal 10; and campomelic dysplasia. Orthologous to human SOX9 (SRY-box transcription factor 9).
Genome Resources: Alliance (1),  Gene:60641 (1),  Ensembl(GRCz11):ENSDARG00000003293 (2)
GENE EXPRESSION
All Expression Data: 166 figures from 127 publications
Wild-type Stages, Structures: Gastrula:Bud (10.0h-10.33h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi1134Tg Transgenic Insertion Acceptor Splice Site of Exon 2 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sox9a_unspecified Unspecified Unknown Unknown
    tw37 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • zc81Tg Transgenic Insertion Unknown Unknown DNA
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-sox9a N/A 2
    MO2-sox9a N/A 6
    MO3-sox9a N/A 4
    MO4-sox9a N/A 1
    MO5-sox9a N/A 1
    MO6-sox9a N/A 1
    MO7-sox9a N/A 2
    DISEASE ASSOCIATED WITH sox9a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    campomelic dysplasia Alliance Acampomelic campomelic dysplasia 114290
    Campomelic dysplasia 114290
    Campomelic dysplasia with autosomal sex reversal 114290
    DISEASE ASSOCIATED WITH sox9a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process inner ear development (more)
    Cellular Component cytoplasm (more)
    Molecular Function chromatin binding (more)
    GO Terms (all 25)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA sox9a-201 (1)    Ensembl 1784
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab2-sox9 monoclonal IgG2a , k Mouse IHC Abcam plc
    4
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM sox9a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-2.4shha-E1:GFP) shhasox9a GFP Danio rerio 1 2
    MARKER RELATIONSHIPS
    sox9a Contained in: [BAC] CH73-314D5 (1)
    sox9a Encodes: [EST] fj17b12
    [cDNA] MGC:111921 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131643 (1) 1790 nt
    Genomic GenBank:CU074420 (1) 97020 nt
    Select Tool
    Polypeptide UniProtKB:Q9DFH2 (1) 462 aa
    Sequence Information (all 23)
    ORTHOLOGY for sox9a ( Chr: 12 )
    CITATIONS (263)