FIGURE

Fig. 4

ID

ZDB-FIG-140319-68

Publication

Nguyen et al., 2000 - Dorsal and intermediate neuronal cell types of the spinal cord are established by a BMP signaling pathway

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Fig. 4

Examination of floor plate and motorneurons in dorsalized mutant embryos. shh expression in wild-type (A), swr/bmp2b (B), sbn/smad5 (C) and snh/bmp7 (D) mutant embryos at the 14-somite stage. The axis of the wild-type embryo (inset A) is straight, while the axis of the swr/bmp2b mutant (inset B) is curved. An intermediate dorsoventral spinal cord position of lim1+ cells in a cross-section of a 14-somite-stage wild-type embryo (E). Crosssections of 14-somite-stage embryos showing floor plate shh expression 1 cell wide in wild-type (F) and 2 to 5 cells wide in snh/bmp7 (G,J), swr/bmp2bsbn/smad5 (I). lim3 expression in the motorneurons of 7-somite-stage wild-type (K) and snh/bmp7 (L) mutant embryo. Expression of isl1 in the RB neurons and motorneurons in wild-type (M) and swr/bmp2b (N), where the motorneurons are apparent, but RB cells are absent. Anterior is to the top, dorsal to the right in A. Anterior is to the left, dorsal to the top in B-D. In K-N, dorsal views, anterior is to the left. FP, floor plate; P, pronephric region.

Expression Data

Genes:	isl1a lhx1a lhx3 shha
Fish:	WT bmp2b^ta72a/ta72a bmp7a^ty68a/ty68a smad5^dtc24/+
Anatomical Terms:	floor plate interneuron motor neuron neural rod notochord notochord cell Rohon-Beard neuron
Stage Range:	5-9 somites to 14-19 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	bmp2b^ta72a/ta72a bmp7a^ty68a/ty68a smad5^dtc24/+
Observed In:	floor plate Rohon-Beard neuron
Stage Range:	5-9 somites to 14-19 somites

Phenotype Detail

Acknowledgments

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