Gene
lhx3
- ID
- ZDB-GENE-980526-131
- Name
- LIM homeobox 3
- Symbol
- lhx3 Nomenclature History
- Previous Names
-
- lim3
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in ventral spinal cord interneuron specification. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in panhypopituitarism. Is expressed in adenohypophyseal placode; nervous system; neural keel; and neural tube. Orthologous to human LHX3 (LIM homeobox 3).
- Genome Resources
-
- Alliance (1)
- Gene:30455 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- 49 figures from 32 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu264 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypopituitarism | Alliance | Pituitary hormone deficiency, combined, 3 | 221750 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017970 | Homeobox, conserved site |
| Domain | IPR001356 | Homeodomain |
| Domain | IPR001781 | Zinc finger, LIM-type |
| Domain | IPR049593 | LIM/homeobox protein Lhx3, LIM domain 1 |
| Domain | IPR049594 | LIM/homeobox protein Lhx3/4-like, LIM domain 2 |
| Family | IPR050453 | LIM/homeobox transcription factors |
| Homologous_superfamily | IPR009057 | Homedomain-like superfamily |
Domain Details Per Protein
| Protein | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | LIM/homeobox protein Lhx3/4-like, LIM domain 2 | LIM/homeobox protein Lhx3, LIM domain 1 | LIM/homeobox transcription factors | Zinc finger, LIM-type |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0G2KNU1
|
||||||||
|
UniProtKB:Q90421
|
398 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance