FIGURE

Fig. 2

ID

ZDB-FIG-140319-64

Publication

Nguyen et al., 2000 - Dorsal and intermediate neuronal cell types of the spinal cord are established by a BMP signaling pathway

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Fig. 2

Expansion of lim1+ interneurons and loss of pronephric precursors in swr/bmp2b, sbn/smad5 and snh/bmp7 mutants. Lateral views with anterior to the top, dorsal to the right in A,F, and anterior to the left and dorsal to the top in B-E,G-I. lim1 expression in 7- somite wild-type (A), swr/bmp2b (B), sbn/smad5 (C, E) and snh/bmp7 (D) mutant embryos. Note the expansion of the interneuron domain in B-D. The insets in A and F are flattened whole-mount embryos. Note the small remnant of the lim1 pronephric domain observed in a sbn/smad5 embryo (E). Expression of pax2.1 in wild-type (F), swr/bmp2b (G), sbn/smad5 (H) and snh/bmp7 (I) embryos. Note the absence of the pax2.1 pronephric domain in swr and snh mutants and the remnant of pronephric expression in the sbn mutant. The otic placode domain is also absent in the swr and snh mutant, but is slightly laterally positioned in the sbn mutant compared to wild-type. * indicates the midbrain-hindbrain boundary domain; IN, interneurons; N, notochord; OP, otic placode; P, pronephric domain.

Expression Data

Genes:	lhx1a pax2a
Fish:	WT bmp2b^ta72a/ta72a bmp7a^ty68a/ty68a smad5^dtc24/+
Anatomical Terms:	interneuron midbrain hindbrain boundary neural rod neural rod notochord cell pronephric mesoderm pronephric mesoderm cell
Stage:	5-9 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	bmp2b^ta72a/ta72a smad5^dtc24/+
Observed In:	interneuron
Stage:	5-9 somites

Phenotype Detail

Acknowledgments

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