FIGURE

Fig. 1

ID

ZDB-FIG-130123-54

Publication

Schweitzer et al., 2013 - Sim1a and Arnt2 contribute to hypothalamo-spinal axon guidance by regulating Robo2 activity via a Robo3-dependent mechanism

Other Figures

All Figure Page

Back to All Figure Page

Fig. 1

Sim1a and Arnt2 act synergistically during longitudinal HTS axon guidance. Dorsal views of hindbrain confocal z-projections of otpb:gfp transgenic embryos at 72 hpf. Anterior is towards the left. (A-H) Mediolateral positioning of otpb:gfp axons (arrows) after indicated treatments. otpb:gfp hindbrain neurons (asterisks in A,C,E,G) do not contribute to longitudinal projections. (I) Quantification of the distance between otpb:gfp axons (I), of the distance between MA neurons (II) or between otpb:gfp hindbrain neurons (III). ^*P<0.0001 for sim1a MO 1.0 ng, arnt2 MO 4.5 ng, arnt2/sim1a MO 1.0/4.5 ng versus control MO 4.5 ng. Scale bar: 50 μm.

Expression Data

Gene:	EGFP
Antibody:	Ab-3A10
Fish:	zc49Tg zc49Tg + MO2-sim1a zc49Tg + MO3-arnt2 zc49Tg + MO2-sim1a + MO3-arnt2
Knockdown Reagents:	MO2-sim1a MO3-arnt2
Anatomical Terms:	diencephalic nucleus axon hindbrain neuron hindbrain nucleus axon Mauthner neuron Mauthner neuron axon
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	zc49Tg + MO2-sim1a zc49Tg + MO3-arnt2 zc49Tg + MO2-sim1a + MO3-arnt2
Knockdown Reagents:	MO2-sim1a MO3-arnt2
Observed In:	diencephalic nucleus axon hindbrain medial region
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Development