FIGURE

Fig. S7

ID

ZDB-FIG-120329-29

Publication

Hozumi et al., 2012 - DEAD-Box Protein Ddx46 Is Required for the Development of the Digestive Organs and Brain in Zebrafish

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Fig. S7

Expression of molecular markers for digestive organs and brain is also reduced in the transheterozygote mor^ha4/Ddx46^hi2137 mutant. (A, B) The expression of dla was examined using whole-mount in situ hybridization at 3 dpf. All lateral views, anterior to the left. (C–H) The expression of fabp10a, ptf1a, and ins was examined by whole-mount in situ hybridization at 3.5 dpf. All dorsal views, anterior to the top. The intensity and area of dla, fabp10a, and ptf1a expression were markedly reduced at 3 or 3.5 dpf in the mor^ha4/Ddx46^hi2137 mutants. In contrast, ins expression in this transheterozygote was unchanged at these developmental stages. These phenotypes are the same as those of the Ddx46^{hi2137/hi2137} mutant. Control larvae were sibling WT, mor^ha4/+, or Ddx46^hi2137/+ larvae and had normal phenotypes.

Expression Data

Genes:	dla fabp10a ins ptf1a
Fish:	WT ddx46^ha4/+; ddx46^hi2137Tg/+
Anatomical Terms:	brain endocrine pancreas exocrine pancreas liver retina
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ddx46^ha4/+; ddx46^hi2137Tg/+
Observed In:	exocrine pancreas liver
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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