FIGURE

Fig. 2

ID

ZDB-FIG-120329-2

Publication

Xu et al., 2012 - Nanog-like Regulates Endoderm Formation through the Mxtx2-Nodal Pathway

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Fig. 2

Nanog-like Regulates Endoderm Formation by Activating Nodal
(A) nanog-like knockdown impairs ventrolateral endoderm formation. The endoderm genes mixer, gata5, sox32, and sox17 are absent at the ventrolateral margin in nanog-like-MO1-injected embryos. All views are shown as an animal view with the dorsal side to the right.
(B) ndr1 and ndr2 expression is restricted to the dorsal area in the nanog-like-MO1-injected embryo; ventrolateral expression of both genes can be restored by coinjection of nanog-like mRNA. All views are lateral with the presumptive dorsal side to the right.
(C) Ventrolateral sox32 and sox17 expression can be rescued by ndr1 mRNA. All views are shown as an animal view with the presumptive dorsal side to the right.

Expression Data

Genes:	gata5 mixl1 ndr1 ndr2 sox17 sox32
Fish:	TU TU + MO1-nanog
Knockdown Reagent:	MO1-nanog
Anatomical Terms:	margin margin dorsal region
Stage:	30%-epiboly

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	TU + MO1-nanog
Knockdown Reagent:	MO1-nanog
Observed In:	presumptive endoderm whole organism
Stage:	30%-epiboly

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Cell, 22(3), Xu, C., Fan, Z.P., Müller, P., Fogley, R., Dibiase, A., Trompouki, E., Unternaehrer, J., Xiong, F., Torregroza, I., Evans, T., Megason, S.G., Daley, G.Q., Schier, A.F., Young, R.A., and Zon, L.I., Nanog-like Regulates Endoderm Formation through the Mxtx2-Nodal Pathway, 625-238, Copyright (2012) with permission from Elsevier. Full text @ Dev. Cell