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ZIRC
ZFIN ID: ZDB-GENE-990415-181
Gene Name: nodal-related 2
Gene Symbol: ndr2    Nomenclature History

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Previous Names: Ndr-2, cyc-1 (1), cyc (1), cyclops (1), Znr-1, znr1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have cytokine activity; transforming growth factor beta receptor binding activity; and type I activin receptor binding activity. Involved in several processes, including animal organ development; embryonic morphogenesis; and regionalization. Localizes to the protein-containing complex. Human ortholog(s) of this gene implicated in visceral heterotaxy. Is expressed in several structures, including axis; diencephalon; embryonic structure; forebrain neural keel; and mesoderm. Orthologous to human NODAL (nodal growth differentiation factor).
Genome Resources: Alliance (1), Gene:30292 (1), Ensembl(GRCz11):ENSDARG00000101279 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b16 Deficiency Unknown Unknown G_RAYS
  • Zebrafish International Resource Center (ZIRC) (order this)
  • b426 Unknown Unknown Unknown ENU
    hi2718aTg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m101 Unknown Unknown Unknown ENU
    m122 Unknown Unknown Unknown ENU
    m294 Point Mutation Unknown Missense ENU
    ndr2_unspecified Unspecified Unknown Unknown
    sg1 Point Mutation Unknown Premature Stop ENU
    st5 Deficiency Unknown Unknown ENU
    te262c Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tf219 Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tu43x Unknown Unknown Unknown
  • European Zebrafish Resource Center (EZRC) (order this)
  • DISEASE ASSOCIATED WITH ndr2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    situs inversus Alliance Heterotaxy, visceral, 5 270100
    DISEASE ASSOCIATED WITH ndr2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process dorsal/ventral pattern formation (more)
    Cellular Component protein-containing complex (more)
    Molecular Function growth factor activity (more)
    GO Terms (all 33)
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM ndr2No data available
    MARKER RELATIONSHIPSNo data available
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_139133 (1)
    Polypeptide UniProtKB:A0A0R4IZE5 (1) 505aa
    Sequence Clusters UniGene:18289 (1)
    Sequence Information (all 13)
    ORTHOLOGY for ndr2 (Chr: 12)
    CITATIONS (287)