Gene

ndr1

ID
ZDB-GENE-990415-256
Name
nodal-related 1
Symbol
ndr1 Nomenclature History
Previous Names
  • Ndr-1
  • CHUNP6892
  • sqt
  • squint
  • Znr-2
  • znr2
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to have cytokine activity and type I activin receptor binding activity. Involved in several processes, including animal organ development; positive regulation of fibroblast growth factor receptor signaling pathway; and regionalization. Predicted to localize to extracellular space. Is expressed in embryonic structure; ovary; posterior lateral line primordium; and unfertilized egg. Human ortholog(s) of this gene implicated in visceral heterotaxy. Orthologous to human NODAL (nodal growth differentiation factor).
Genome Resources
Note
None
Expression
All Expression Data
57 figures from 45 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
27 figures from 16 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ndr1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
situs inversus Alliance Heterotaxy, visceral, 5 270100
Associated With ndr1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017948 Transforming growth factor beta, conserved site
Domain IPR001111 TGF-beta, propeptide
Domain IPR001839 Transforming growth factor-beta, C-terminal
Family IPR015615 Transforming growth factor-beta-related
Homologous_superfamily IPR029034 Cystine-knot cytokine
Domain Details Per Protein
Protein Length Cystine-knot cytokine TGF-beta, propeptide Transforming growth factor beta, conserved site Transforming growth factor-beta, C-terminal Transforming growth factor-beta-related
UniProtKB:A0A2R8Q4U4 116
UniProtKB:Q78CR8 116
UniProtKB:O13144 392
UniProtKB:F1QDT8 392
UniProtKB:Q4V930 392
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations