Gene

ndr1

ID

ZDB-GENE-990415-256

Name

nodal-related 1

Symbol

ndr1 Nomenclature History

Previous Names

Ndr-1
CHUNP6892
sqt
squint
Znr-2
znr2

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to enable cytokine activity and type I activin receptor binding activity. Involved in camera-type eye development. Acts upstream of or within several processes, including hypothalamus development; positive regulation of fibroblast growth factor receptor signaling pathway; and regionalization. Part of protein-containing complex. Is expressed in embryonic structure; ovary; posterior lateral line primordium; and unfertilized egg. Human ortholog(s) of this gene implicated in visceral heterotaxy. Orthologous to human NODAL (nodal growth differentiation factor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

61 figures from 49 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 28 figures from 17 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ndr1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
visceral heterotaxy 5	Alliance	Heterotaxy, visceral, 5	270100

Associated With ndr1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017948	Transforming growth factor beta, conserved site
Domain	IPR001111	TGF-beta, propeptide
Domain	IPR001839	Transforming growth factor-beta, C-terminal
Family	IPR015615	Transforming growth factor-beta-related
Homologous_superfamily	IPR029034	Cystine-knot cytokine