FIGURE

Fig. 10

ID

ZDB-FIG-120127-11

Publication

Wong et al., 2012 - Hedgehog signaling is required for differentiation of endocardial progenitors in zebrafish

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Fig. 10

Sox32 function is required for the migration but not differentiation of endocardial precursors. (A–D) Fn1 expression in the endocardial precursors is not affected in the endoderm-deficient sox32 knockdown embryos at the 12-somite stage (A,B) while they fail to migrate towards the midline at the 16-somite stage (C,D). (E,F) Endocardial kdrl expression is absent from the midline in sox32 morphants at the 18-somite stage. (G–L) Myocardial cmlc2 (G,H,K,L) and endocardial NFATc1 expression (I,J) is split bilaterally in sox32 morphants at the 20-somite (G,H) and 26 hpf stages (I-L). Ventral view of flat-mounted embryos, anterior is to the top in all panels.

Expression Data

Genes:	fn1a kdrl myl7 nfatc1
Fish:	WT WT + MO2-sox32
Knockdown Reagent:	MO2-sox32
Anatomical Terms:	endocardial precursor endocardium myocardium
Stage Range:	10-13 somites to Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO2-sox32
Knockdown Reagent:	MO2-sox32
Observed In:	endocardial progenitor cell migration to the midline involved in heart field formation endocardium morphogenesis
Stage:	14-19 somites

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 361(2), Wong, K.S., Rehn, K., Palencia-Desai, S., Kohli, V., Hunter, W., Uhl, J.D., Rost, M.S., and Sumanas, S., Hedgehog signaling is required for differentiation of endocardial progenitors in zebrafish, 377-91, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.