Gene
fn1a
- ID
- ZDB-GENE-000426-1
- Name
- fibronectin 1a
- Symbol
- fn1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Exhibits integrin binding activity. Involved in several processes, including animal organ development; cell migration involved in sprouting angiogenesis; and somite specification. Localizes to interstitial matrix. Human ortholog(s) of this gene implicated in calcium oxalate nephrolithiasis and membranoproliferative glomerulonephritis. Is expressed in several structures, including cardiovascular system; mesoderm; nervous system; tail bud; and yolk. Orthologous to human FN1 (fibronectin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 70 figures from 32 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu146 (15 images)
- eu867 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- 24 figures from 11 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spondylometaphyseal dysplasia corner fracture type | Alliance | Spondylometaphyseal dysplasia, corner fracture type | 184255 |
| Glomerulopathy with fibronectin deposits 2 | 601894 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000083 | Fibronectin, type I |
| Domain | IPR000562 | Fibronectin type II domain |
| Domain | IPR003961 | Fibronectin type III |
| Family | IPR050991 | Extracellular Matrix Regulatory Proteins |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR013806 | Kringle-like fold |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
| Homologous_superfamily | IPR036943 | Fibronectin type II domain superfamily |
Domain Details Per Protein
| Protein | Length | Extracellular Matrix Regulatory Proteins | Fibronectin, type I | Fibronectin type II domain | Fibronectin type II domain superfamily | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin-like fold | Kringle-like fold |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3B2G8
|
2479 | ||||||||
|
UniProtKB:B0S602
|
2480 |
Interactions and Pathways
No data available
Plasmids
No data available