Gene

fn1a

ID
ZDB-GENE-000426-1
Name
fibronectin 1a
Symbol
fn1a Nomenclature History
Previous Names
  • fn1
  • FN1 (1)
  • fn1l (1)
  • FN2 (1)
  • Fn (1)
  • fb80d10
  • nat
  • natter
  • wu:fb80d10 (1)
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Exhibits integrin binding activity. Involved in several processes, including animal organ development; cell migration involved in sprouting angiogenesis; and somite specification. Localizes to interstitial matrix. Is expressed in several structures, including cardiovascular system; mesoderm; nervous system; tail bud; and yolk. Human ortholog(s) of this gene implicated in calcium oxalate nephrolithiasis and membranoproliferative glomerulonephritis. Orthologous to human FN1 (fibronectin 1).
Genome Resources
Note
None
Expression
All Expression Data
59 figures from 23 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
21 figures from 10 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fn1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Glomerulopathy with fibronectin deposits 2 601894
Spondylometaphyseal dysplasia, corner fracture type 184255
Associated With fn1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000083 Fibronectin, type I
Domain IPR000562 Fibronectin type II domain
Domain IPR003961 Fibronectin type III
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR013806 Kringle-like fold
Homologous_superfamily IPR036116 Fibronectin type III superfamily
Homologous_superfamily IPR036943 Fibronectin type II domain superfamily
Domain Details Per Protein
Protein Length Fibronectin, type I Fibronectin type II domain Fibronectin type II domain superfamily Fibronectin type III Fibronectin type III superfamily Immunoglobulin-like fold Kringle-like fold
UniProtKB:Q98TS8 52
UniProtKB:B0S602 2480
UniProtKB:F1RBP8 2480
UniProtKB:B3DGZ1 2480
UniProtKB:O93405 922
UniProtKB:A0A2R8Q0R2 44
UniProtKB:O93406 2478
UniProtKB:Q98TS9 42
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations