ZFIN ID: ZDB-GENE-000426-1
Gene Name: fibronectin 1a
Gene Symbol: fn1a    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: fn1, FN1 (1), fn1l (1), FN2 (1), Fn (1), fb80d10, nat, natter, wu:fb80d10 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Exhibits integrin binding activity. Involved in several processes, including animal organ development; cell migration involved in sprouting angiogenesis; and somite specification. Localizes to the interstitial matrix. Human ortholog(s) of this gene implicated in membranoproliferative glomerulonephritis. Is expressed in several structures, including cardiovascular system; mesoderm; nervous system; tail bud; and yolk. Orthologous to human FN1 (fibronectin 1).
Genome Resources: Alliance (1),  Gene:100005469 (1),  Ensembl(GRCz11):ENSDARG00000019815 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
kt259 Point Mutation Unknown Premature Stop ENU
la016487Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa6112 Point Mutation Unknown Splice Site ENU
    sa7625 Point Mutation Unknown Missense ENU
    sa12585 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21452 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21453 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa27365 Point Mutation Unknown Premature Stop ENU
    sa27366 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa27367 Point Mutation Unknown Premature Stop ENU
    sa34593 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34594 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • ta219 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tl43c Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-fn1a N/A 13
    MO2-fn1a N/A 1
    MO3-fn1a N/A 2
    MO4-fn1a N/A 1
    DISEASE ASSOCIATED WITH fn1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Glomerulopathy with fibronectin deposits 2 601894
    Spondylometaphyseal dysplasia, corner fracture type 184255
    DISEASE ASSOCIATED WITH fn1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cardioblast migration to the midline involved in heart rudiment formation (more)
    Cellular Component interstitial matrix (more)
    Molecular Function integrin binding (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000083 Fibronectin, type I
    Domain IPR000562 Fibronectin type II domain
    Domain IPR003961 Fibronectin type III
    Homologous_superfamily IPR013783 Immunoglobulin-like fold
    Homologous_superfamily IPR013806 Kringle-like fold
    Homologous_superfamily IPR036116 Fibronectin type III superfamily
    Homologous_superfamily IPR036943 Fibronectin type II domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA fn1a-202 (1)    Ensembl 8776
    ncRNA fn1a-002 (1)    Ensembl 3022
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM fn1a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(tbx16l:fn1a-emGFP) tbx16l emGFPfn1a Danio rerio 1 1
    TgBAC(fn1a:NTR-mCherry) fn1a mCherryNTR Danio rerio 1 4
    MARKER RELATIONSHIPS
    fn1a Contained in: [BAC] DKEY-30L22 (1) (order this)
    fn1a Encodes: [EST] eu146 (1), eu867 (1), fb80d10 (1) (order this)
    [cDNA] MGC:193819
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131520 (1) 8267 nt
    Genomic GenBank:BX323049 (1) 214040 nt Blast at MegaBLAST
    Polypeptide UniProtKB:B0S602 (1) 2480 aa
    Sequence Information (all 31)
    ORTHOLOGY for fn1a ( Chr: 9 )
    CITATIONS (93)