Gene

nfatc1

ID

ZDB-GENE-060503-677

Name

nuclear factor of activated T cells 1

Symbol

nfatc1 Nomenclature History

Previous Names

si:ch211-198c22.2

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to have several functions, including DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in response to mechanical stimulus. Predicted to localize to cytosol and nuclear transcription factor complex. Is expressed in several structures, including adaxial cell; heart; olfactory system; scale; and tail bud. Orthologous to human NFATC1 (nuclear factor of activated T cells 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

28 figures from 16 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nfatc1 Human Ortholog

No data available

Associated With nfatc1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002909	IPT domain
Domain	IPR011539	Rel homology domain, DNA-binding domain
Domain	IPR032397	Rel homology dimerisation domain
Family	IPR008366	Nuclear factor of activated T cells (NFAT)
Homologous_superfamily	IPR008967	p53-like transcription factor, DNA-binding domain superfamily
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR014756	Immunoglobulin E-set
Homologous_superfamily	IPR037059	Rel homology domain (RHD), DNA-binding domain superfamily