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ZFIN ID: ZDB-FIG-111215-27
Melville et al., 2011 - The feelgood mutation in zebrafish dysregulates COPII-dependent secretion of select extracellular matrix proteins in skeletal morphogenesis. Disease models & mechanisms   4(6):763-76 Full text @ Dis. Model. Mech.
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage: Day 5

Fig. 4 Melanophore development is disrupted in feelgood mutants. (A–D) Live image of melanophores in the trunk of 6-dpf wild-type (WT) and feelgood mutants in untreated (A,B) and 0.5 μg/ml 4-hydroxyanisole treated (C,D) embryos. (E) Summary drawing of the stages of melanosome maturation comparing normal and feelgood melanocytes. (F,G) TEM images of 5-dpf melanosomes. Arrows point to a mature melanosome in WT (F), and a round, dark, stage IV melanosome in feelgood (G). Scale bar: 1 μm.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
creb3l2m662/m662(AB) standard conditions Day 5 melanocyte melanosome circular, abnormal
Day 5 melanocyte melanosome immature, abnormal
Day 5 melanosome organization decreased process quality, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Disease models & mechanisms for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Dis. Model. Mech.