FIGURE

Fig. 4

ID

ZDB-FIG-111026-16

Publication

Lu et al., 2011 - Induction of apoptosis and inhibition of cell growth by tbx5 knockdown contribute to dysmorphogenesis in Zebrafish embryos

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Fig. 4

Sagittal view of the heart in tbx5 knockdown embryos by immunohistochemical studies of heart. A-B: Caspase-3 (red) expression could been slightly seen in wild-type (WT) embryos (A), but caspase-3 was more induced in knockdown embryos at 48 h post-fertilization (hpf) though the expression was not so strong (B). Caspase-8 (blue) was more induced in knockdown embryos (D) at 48 h post-fertilization (hpf) than the expression in wild-type (C). The proapoptotic factor, BAD (red), was enhanced in tbx5 deficiency embryos (F) with the nucleus stained by DAPI (blue); but there was almost no BAD expression in WT embryos (E). Compared to the WT (G), embryos with tbx5 deficiency showed a significant increase in BLC2 expression (H). The anterior of embryos is to the left. h, heart; MO, tbx5-MO-treated embryos.

Expression Data

Gene:	casp8
Antibody:	Ab1-casp8
Fish:	WT WT + MO1-tbx5a
Knockdown Reagent:	MO1-tbx5a
Anatomical Term:	heart
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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