FIGURE

Fig. 3

ID

ZDB-FIG-100211-22

Publication

Kok et al., 2010 - Churchill and Sip1a repress fibroblast growth factor signaling during zebrafish somitogenesis

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Fig. 3

Inhibition of ChCh and Sip1a affects the components of the "clock and wavefront model." A-I: Flat-mount RNA in situ hybridization of 10-somite stage wild-type, and ChCh and Sip1a compromised embryos. All views are dorsal; anterior to the left. A-F: In wild-type embryos, periodic activation of Notch signaling provides cycling gene expression of Notch pathway genes such as her1 and her7. The number of the her7 expressing stripes in chch and sip1a ATG MO injected embryos ranges from 4 to 5 (B,C; E,F). G-I: fgf8 expression domain at tail bud is expanded anteriorly in ChCh and Sip1a compromised embryos. A-F: Asterisks denote each her1 or her7 expressing premesoderm stripe. G-I: Arrows denote fgf8 tail bud expression domain (G-I).

Expression Data

Genes:	fgf8a her1 her7
Fish:	WT WT + MO2-churc1 WT + MO4-zeb2a
Knockdown Reagents:	MO2-churc1 MO4-zeb2a
Anatomical Terms:	segmental plate somite tail bud
Stage:	10-13 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO2-churc1 WT + MO4-zeb2a
Knockdown Reagents:	MO2-churc1 MO4-zeb2a
Observed In:	segmental plate somite somite rostral/caudal axis specification tail bud
Stage:	10-13 somites

Phenotype Detail

Acknowledgments

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