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Somite malformation in ChCh and Sip1a compromised embryos can be rescued by reduction of fibroblast growth factor-8 (FGF8). A,B: Dorsal views of 10-somite stage (A) and 12-somite stage (B) living embryos, anterior to the top. A: Somites are narrower at the anterior-posterior (A/P) axis, broader at the mediolateral axis in wild-type and ace heterozygous chch morphants, but not ace homozygous chch morphants. ace homozygous sip1a ATG morphants do not have somite phenotype, but wild-type and ace heterozygous sip1a morphants still have the somite defects. B: Horizontal and vertical red dotted line spans the first five somites of the control injected embryo width and length for comparison to the first five somite of morphant embryos which is indicated with a black line. Embryos were genotyped for the ace allele after imaging.
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