Gene
her7
- ID
- ZDB-GENE-000427-6
- Name
- hairy and enhancer of split related-7
- Symbol
- her7 Nomenclature History
- Previous Names
-
- cb715 (1)
- her7-protein
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Enables identical protein binding activity. Acts upstream of or within somite specification. Predicted to be active in nucleus. Is expressed in several structures, including liver; margin; mesoderm; presumptive mesoderm; and tail bud.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 46 figures from 34 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb715 (11 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-her7 | Yabe et al., 2023 | |
| MO1-her7 | N/A | (7) |
| MO2-her7 | N/A | (4) |
| MO3-her7 | N/A | Gajewski et al., 2003 |
| MO4-her7 | N/A | (5) |
| MO5-her7 | N/A | (2) |
| MO6-her7 | N/A | (3) |
| TALEN1-her7 | Yabe et al., 2023 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Hairy and Enhancer of Split/HEY-related | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | Orange domain |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PKJ6
|
221 | ||||
|
UniProtKB:Q9I9K1
|
206 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(her7:her7-Venus) |
|
|
| 1 | (2) |
| Tg(hes6-hsp70l:EGFP-UTR-her7) |
| 1 | Fujino et al., 2018 | ||
| Tg(hsp70l:her7) |
|
| 1 | (7) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-283H6 | ZFIN Curated Data | |
| Encodes | EST | cb715 | Thisse et al., 2001 | |
| Encodes | cDNA | MGC:195298 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195312 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131609 (1) | 1111 nt | ||
| Genomic | GenBank:BX537304 (1) | 157564 nt | ||
| Polypeptide | UniProtKB:A0A8M9PKJ6 (1) | 221 aa |
No data available
- Keseroglu, K., Zinani, O.Q.H., Keskin, S., Seawall, H., Alpay, E.E., Özbudak, E.M. (2023) Stochastic gene expression and environmental stressors trigger variable somite segmentation phenotypes. Nature communications. 14:64976497
- Yabe, T., Uriu, K., Takada, S. (2023) Ripply suppresses Tbx6 to induce dynamic-to-static conversion in somite segmentation. Nature communications. 14:21152115
- Naganathan, S.R., Popović, M., Oates, A.C. (2022) Left-right symmetry of zebrafish embryos requires somite surface tension. Nature. 605(7910):516-521
- Özelçi, E., Mailand, E., Rüegg, M., Oates, A.C., Sakar, M.S. (2022) Deconstructing body axis morphogenesis in zebrafish embryos using robot-assisted tissue micromanipulation. Nature communications. 13:79347934
- Simsek, M.F., Chandel, A.S., Saparov, D., Zinani, O.Q.H., Clason, N., Özbudak, E.M. (2022) Periodic inhibition of Erk activity drives sequential somite segmentation. Nature. 613(7942):153-159
- Zhang, W., Scerbo, P., Delagrange, M., Candat, V., Mayr, V., Vriz, S., Distel, M., Ducos, B., Bensimon, D. (2022) Fgf8 dynamics and critical slowing down may account for the temperature independence of somitogenesis. Communications biology. 5:113
- Zinani, O.Q.H., Keseroğlu, K., Dey, S., Ay, A., Singh, A., Özbudak, E.M. (2022) Gene copy number and negative feedback differentially regulate transcriptional variability of segmentation clock genes. iScience. 25:104579
- Kuretani, A., Yamamoto, T., Taira, M., Michiue, T. (2021) Evolution of hes gene family in vertebrates: the hes5 cluster genes have specifically increased in frogs. BMC ecology and evolution. 21:147
- Guo, Y., Cheng, B.Y.L., Wang, D., Ma, A.C.H., He, B.L., Man, T.K., Cheung, M.P.L., Shi, X., Ng, N.K.L., Leung, A.Y.H. (2020) Function of Arl4aa in the Initiation of Hematopoiesis in Zebrafish by Maintaining Golgi Complex Integrity in Hemogenic Endothelium. Stem Cell Reports. 14(4):575-589
- Lleras-Forero, L., Newham, E., Teufel, S., Kawakami, K., Hartmann, C., Hammond, C.L., Knight, R.D., Schulte-Merker, S. (2020) Muscle defects due to perturbed somite segmentation contribute to late adult scoliosis. Aging. 12(18):18603-18621
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