FIGURE

Fig. 1

ID

ZDB-FIG-100211-20

Publication

Kok et al., 2010 - Churchill and Sip1a repress fibroblast growth factor signaling during zebrafish somitogenesis

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Fig. 1

ChCh and Sip1a are required for somitogenesis. A-S: Living wild-type, and ChCh and Sip1a compromised embryos. A-E: Early epiboly movements appear normal in chch or sip1a morphants. F-J: By 12 somites, misshapen somites are apparent in both chch and sip1 morpholino treated embryos. K-O: In these embryos, somites are less extended through the anterior-posterior axis and overextended through the mediolateral axis. Horizontal and vertical red dotted lines span the width and length of the first four wild-type somites for comparison to the first four somites of morphant embryos, which are marked with a black line. P-S: At 24 hours post fertilization (hpf), somites are enlarged and misshapen in both ChCh and Sip1a compromised embryos. Arrowheads denote notochord and black arrows denote somites. A-J,P-S are lateral views; K-O, dorsal views.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-churc1 WT + MO2-churc1 WT + MO3-zeb2a WT + MO4-zeb2a
Knockdown Reagents:	MO1-churc1 MO2-churc1 MO3-zeb2a MO4-zeb2a
Observed In:	epiboly involved in gastrulation with mouth forming second somite somite anterior-posterior axis somite medial-lateral axis somitogenesis trunk whole organism anterior-posterior axis whole organism medial-lateral axis
Stage Range:	50%-epiboly to Prim-5

Phenotype Detail

Acknowledgments

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