Fig. 1

Fig. 1 ChCh and Sip1a are required for somitogenesis. A-S: Living wild-type, and ChCh and Sip1a compromised embryos. A-E: Early epiboly movements appear normal in chch or sip1a morphants. F-J: By 12 somites, misshapen somites are apparent in both chch and sip1 morpholino treated embryos. K-O: In these embryos, somites are less extended through the anterior-posterior axis and overextended through the mediolateral axis. Horizontal and vertical red dotted lines span the width and length of the first four wild-type somites for comparison to the first four somites of morphant embryos, which are marked with a black line. P-S: At 24 hours post fertilization (hpf), somites are enlarged and misshapen in both ChCh and Sip1a compromised embryos. Arrowheads denote notochord and black arrows denote somites. A-J,P-S are lateral views; K-O, dorsal views.