FIGURE

Fig. 2

ID

ZDB-FIG-091014-2

Publication

Kinkel et al., 2009 - Cyp26 enzymes function in endoderm to regulate pancreatic field size

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Fig. 2

Cyp26 inhibition expands the pancreas anteriorly. (A and B) pdx1 labels cells of the pancreas and anterior small intestine. (C and D) insulin (ins) labels β-cells. (E and F) insulin (ins), lateral view. (G and H) glucagon (gcga) labels α-cells. (I and J) somatostatin 2 (sst2) labels δ-cells. (K and L) islet1 labels endocrine pancreas; lateral view. (M and N) cebpa labels liver and intestine. (O and P) foxa2 labels pharyngeal endoderm. Arrowheads indicate endoderm. The dorsal view is shown unless otherwise indicated, anterior to left.

Expression Data

Genes:	cebpa foxa2 gcga ins isl1a pdx1 sst2 (all 7)
Fish:	WT
Condition:	chemical treatment: talarozole
Anatomical Terms:	gut intestine liver pancreas primordium pharyngeal endoderm posterior pancreatic bud (all 6)
Stage Range:	Prim-5 to Long-pec

Expression Detail

Gene	Fish	Conditions	Stage	Anatomy	Assay
cebpa	WT	control	Long-pec	intestine	ISH
cebpa	WT	control	Long-pec	liver	ISH
cebpa	WT	chemical treatment: talarozole	Long-pec	intestine	ISH
cebpa	WT	chemical treatment: talarozole	Long-pec	liver	ISH
foxa2	WT	control	Prim-15	pharyngeal endoderm	ISH
foxa2	WT	chemical treatment: talarozole	Prim-15	pharyngeal endoderm	ISH
gcga	WT	control	Prim-15	posterior pancreatic bud	ISH
gcga	WT	chemical treatment: talarozole	Prim-15	posterior pancreatic bud	ISH
ins	WT	control	Prim-5	posterior pancreatic bud	ISH
ins	WT	chemical treatment: talarozole	Prim-5	posterior pancreatic bud	ISH

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Antibody Labeling

No data available

Phenotype Data

Fish:	WT
Condition:	chemical treatment: talarozole
Observed In:	endoderm pancreas pancreas development pharyngeal endoderm retinoic acid catabolic process
Stage Range:	Prim-5 to Long-pec

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA