Gene

foxa2

ID
ZDB-GENE-980526-404
Name
forkhead box A2
Symbol
foxa2 Nomenclature History
Previous Names
  • ax
  • axl
  • axial (1)
  • etID309811.17 (1)
  • fkd1 (1)
  • HNF-3B
  • hnf3b
  • ik:tdsubc_2g8
  • mol
  • monorail
  • tdsubc_2g8
  • wu:fe05g04 (1)
  • xx:tdsubc_2g8
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Exhibits transcription regulatory region sequence-specific DNA binding activity. Involved in axial mesoderm morphogenesis; endoderm development; and nervous system development. Predicted to localize to nuclear chromatin. Is expressed in several structures, including central nervous system; digestive system; endoderm; mesoderm; and swim bladder. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human FOXA2 (forkhead box A2).
Genome Resources
Note
None
Expression
All Expression Data
146 figures from 115 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With foxa2 Human Ortholog
No data available
Associated With foxa2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018122 Fork head domain conserved site1
Conserved_site IPR030456 Fork head domain conserved site 2
Domain IPR001766 Fork head domain
Domain IPR013638 Fork-head N-terminal
Domain IPR018533 Forkhead box protein, C-terminal
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Forkhead box protein, C-terminal Fork head domain Fork head domain conserved site1 Fork head domain conserved site 2 Fork-head N-terminal Winged helix DNA-binding domain superfamily Winged helix-like DNA-binding domain superfamily
UniProtKB:F1Q819 409
UniProtKB:Q5PRD6 409
UniProtKB:Q07342 409
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations