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ZIRC
ZFIN ID: ZDB-GENE-020111-2
Gene Name: CCAAT enhancer binding protein alpha
Gene Symbol: cebpa    Nomenclature History

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Previous Names: c/ebpa (1), cb1062 (1), chunp6777, fj20f03, unm_sm1120, wu:fj20f03 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Exhibits DNA binding activity and DNA-binding transcription factor activity. Involved in hematopoietic stem cell migration; hemopoiesis; and liver development. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Is expressed in several structures, including digestive system; hematopoietic cell; hematopoietic system; mesoderm; and yolk syncytial layer. Orthologous to human CEBPA (CCAAT enhancer binding protein alpha).
Genome Resources: Alliance (1),  Gene:140815 (1),  Ensembl(GRCz11):ENSDARG00000036074 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hkz7 Insertion Exon 1 Unknown ENU
rj31 Small Deletion Unknown Frameshift, Premature Stop TALEN
sa18352 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sm4a Small Deletion Exon 1 Frameshift, Premature Stop TALEN
    sm4b Insertion Exon 1 Frameshift, Premature Stop TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-cebpa
    2
    TALEN1-cebpa 3
    TALEN2-cebpa 1
    DISEASE ASSOCIATED WITH cebpa HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    acute myeloid leukemia Alliance Leukemia, acute myeloid, somatic 601626
    ?Leukemia, acute myeloid 601626
    DISEASE ASSOCIATED WITH cebpa VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process definitive hemopoiesis (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR004827 (1)
  • InterPro:IPR016468 (1)
  • PROSITE:PS50217 (1)
  • Pfam:PF07716 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cebpa-201 (1)    Ensembl 2880
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cebpa
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(lmo2:LOXP-DsRed-LOXP-EGFP-dncebpa) lmo2 cebpaDsRedEGFP Danio rerio 1 3
    MARKER RELATIONSHIPS
    cebpa Contained in: [BAC] DKEY-27K4 (1) (order this)
    cebpa Encodes: [EST] cb1062 (1) (order this), fj20f03
    [cDNA] MGC:65751 (1) (order this), MGC:77578 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131885 (1) 2896 bp
    Genomic GenBank:BX323060 (1) 251050 bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q8UVZ1 (1) 288 aa
    Sequence Clusters UniGene:78568 (1)
    Sequence Information (all 16)
    ORTHOLOGY for cebpa ( Chr: 7 )
    CITATIONS (108)