FIGURE

Fig. S3

ID

ZDB-FIG-090710-73

Publication

Aanstad et al., 2009 - The Extracellular Domain of Smoothened Regulates Ciliary Localization and Is Required for High-Level Hh Signaling

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Fig. S3

SmoC151Y fails to localize to the cilium.
Expression of the ciliary marker acetylated Tubulin (green) and Myc-tagged (red) wild-type Smo (A), Myc-tagged SmoC151Y (B) or CLDSmo (C-D) in NIH 3T3 cells. Nuclei were visualized with DAPI (blue). Low levels of wild-type Smo expression did not cause its ciliary localization in the absence of Shh or purmorphamine; SmoC151Y or CLDSmo was not detected on the cilia even in the presence of Shh or purmorphamine (see also Suppl. Fig. 5).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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