ZFIN ID: ZDB-FIG-090501-2
Bmp signaling is tightly regulated in the tailbud during early somitogenesis. (A, B) Bmp signaling is active in the mesodermal progenitor zone. Expression of no tail is shown by FISH in green in 3-somite stage embryos marking both the mesodermal progenitor zone and the notochord (n). Bmp signaling is indicated by antibody staining for phosphorylated Smad proteins (red in B–D). Bmp inhibitors are expressed just anterior to the activated Smad zone. The Bmp inhibitors chordin, noggin1 and noggin2 are shown by FISH in green and the Smad staining is shown in red in 3-somite (C) and 12-somite (D) embryos. All embryos are shown from a dorsal view with anterior to the top.
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Reprinted from Developmental Biology, 329(1), Row, R., and Kimelman, D., Bmp inhibition is necessary for post-gastrulation patterning and morphogenesis of the zebrafish tailbud, 55-63, Copyright
(2009) with permission from Elsevier.
Full text @ Dev. Biol.