FIGURE

Fig. 4

ID

ZDB-FIG-090501-5

Publication

Row et al., 2009 - Bmp inhibition is necessary for post-gastrulation patterning and morphogenesis of the zebrafish tailbud

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Fig. 4

Ectopic Bmp signaling during early somitogenesis alters patterning and morphogenesis. (A, B) Expression of no tail is expanded in the tailbud of transgenic embryos at the 9-somite stage. (C–E) Cell migration, as shown by photoconverted NLS-Kikume fluorescence (red), is disrupted as a result of ectopic Bmp signaling. The graph shows the most anteriorward migration of labeled cells from the posterior end of the embryo in individual embryos. (F, G, H) Cell migration defects are a non-cell-autonomous result of ectopic Bmp signaling. Cell transplants were performed as diagrammed in (F). Cells from a transgenic donor (H) contribute to the same cell types and anterior extent as those from a wild-type donor (G). Embryos were heat shocked at the 3-somite stage.

Expression Data

Gene:	tbxta
Fish:	WT w64Tg/+
Condition:	heat shock
Anatomical Terms:	notochord tail bud
Stage:	5-9 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	w64Tg (WIK/AB)
Condition:	heat shock
Observed In:	convergent extension involved in axis elongation convergent extension involved in somitogenesis post-vent region tail bud
Stage:	14-19 somites

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 329(1), Row, R., and Kimelman, D., Bmp inhibition is necessary for post-gastrulation patterning and morphogenesis of the zebrafish tailbud, 55-63, Copyright (2009) with permission from Elsevier. Full text @ Dev. Biol.