FIGURE

Fig. 8

ID

ZDB-FIG-090408-55

Publication

Schebesta et al., 2009 - olig1 expression identifies developing oligodendrocytes in zebrafish and requires hedgehog and notch signaling

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Fig. 8

Olig1 knockdown alone does not interfere with oligodendrocyte development unless combined with an Olig2 sensitized background. A: Injection of 750 μM olig1 morpholino (olig-1-MO) alone had no effect on mpb or plp expression at 96 hpf while 250 μM olig2-MO abolished mbp expression in the CNS. B: In contrast, co-injection of 750 μM olig1-MO with low concentrations of olig2-MO (75 μM), each morpholino individually having no phenotype, reduced mbp⁺ oligodendrocytes. Numbers in columns indicate numbers of observed embryos while n indicates total number of analyzed embryo per treatment/injection.

Expression Data

Genes:	mbpa plp1b
Fish:	WT WT + MO1-olig1 WT + MO1-olig2 WT + MO1-olig1 + MO1-olig2
Knockdown Reagents:	MO1-olig1 MO1-olig2
Anatomical Term:	oligodendrocyte
Stage:	Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-olig2 WT + MO1-olig1 + MO1-olig2
Knockdown Reagents:	MO1-olig1 MO1-olig2
Observed In:	oligodendrocyte development
Stage:	Day 4

Phenotype Detail

Acknowledgments

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