Gene

plp1b

ID
ZDB-GENE-030710-6
Name
proteolipid protein 1b
Symbol
plp1b Nomenclature History
Previous Names
  • dm20 (1)
  • DMalpha2a
  • DMalpha2b
  • DMalpha2c
  • fv76c02
  • wu:fv76c02
  • zgc:91786
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to be a structural constituent of myelin sheath. Predicted to be involved in axon development and central nervous system myelination. Predicted to localize to myelin sheath and plasma membrane. Is expressed in nervous system. Human ortholog(s) of this gene implicated in Pelizaeus-Merzbacher disease and hereditary spastic paraplegia 2. Orthologous to human PLP1 (proteolipid protein 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
30 figures from 15 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With plp1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hereditary spastic paraplegia 2 Alliance Spastic paraplegia 2, X-linked 312920
Pelizaeus-Merzbacher disease Alliance Pelizaeus-Merzbacher disease 312080
Associated With plp1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR001614 Myelin proteolipid protein PLP
Domain Details Per Protein
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations