ZFIN ID: ZDB-GENE-030710-6
Gene Name: proteolipid protein 1b
Gene Symbol: plp1b    Nomenclature History

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Previous Names: dm20 (1), DMalpha2a, DMalpha2b, DMalpha2c, fv76c02, wu:fv76c02, zgc:91786

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to be a structural constituent of myelin sheath. Predicted to be involved in axon development and central nervous system myelination. Predicted to localize to myelin sheath and plasma membrane. Is expressed in nervous system. Human ortholog(s) of this gene implicated in Pelizaeus-Merzbacher disease and hereditary spastic paraplegia 2. Orthologous to human PLP1 (proteolipid protein 1).
Genome Resources: Alliance (1),  Gene:368234 (1),  Ensembl(GRCz11):ENSDARG00000011929 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH plp1b HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hereditary spastic paraplegia 2 Alliance Spastic paraplegia 2, X-linked 312920
Pelizaeus-Merzbacher disease Alliance Pelizaeus-Merzbacher disease 312080
DISEASE ASSOCIATED WITH plp1b VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process axon development (more)
Cellular Component integral component of membrane (more)
Molecular Function structural constituent of myelin sheath (more)
GO Terms (all 8)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA plp1b-201 (1)    Ensembl 1810
plp1b-202 (1)    Ensembl 1717
plp1b-203 (1)    Ensembl 1615
plp1b-204 (1)    Ensembl 1723
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM plp1b No data available
MARKER RELATIONSHIPS
plp1b Contained in: [BAC] DKEY-125I10 (1) (order this)
plp1b Encodes: [EST] eu446 (1), fj36d03 (1), fv76c02
[cDNA] MGC:91786 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001005586 (1) 1811 nt
Genomic GenBank:BX640521 (1) 126380 nt
Select Tool
Polypeptide UniProtKB:Q8UUT3 (1) 279 aa
Sequence Information (all 29)
ORTHOLOGY for plp1b ( Chr: 5 )
CITATIONS (43)