ZFIN Morpholino: MO1-olig2

Target Location

Genome Build: GRCz11Chromosome: 9

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-olig2

Expressed Gene	Anatomy	Figures
irx3a	central nervous system	Fig. 4 from Lewis et al., 2005
isl2a	(not) primary motor neuron Rohon-Beard neuron	Fig. 5 from Park et al., 2002
mbpa	(not) oligodendrocyte	Fig. 8 from Schebesta et al., 2009
plp1a	(not) spinal cord oligodendrocyte	Fig. 6 from Park et al., 2002
plp1b	oligodendrocyte	Fig. 8 from Schebesta et al., 2009

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Phenotype

Phenotype resulting from MO1-olig2

Phenotype	Fish	Figures
dopaminergic neuron decreased amount, abnormal	WT + MO1-olig2	Fig. 5 from Borodovsky et al., 2009
motor neuron lacks parts or has fewer parts of type motor neuron axon, abnormal	y1Tg/+ + MO1-olig2	Fig. 7 from Lim et al., 2011
oligodendrocyte development disrupted, abnormal	WT + MO1-olig2	Fig. 8 from Schebesta et al., 2009 Fig. 6 from Park et al., 2002
parachordal vessel immature, abnormal	y1Tg/+ + MO1-olig2	Fig. 7 from Lim et al., 2011
parachordal vessel venous endothelial cell migration involved in lymph vessel development arrested, abnormal	y1Tg/+ + MO1-olig2	Fig. 7 from Lim et al., 2011

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Phenotype of all Fish created by or utilizing MO1-olig2

Phenotype	Fish	Conditions	Figures
spinal cord motor neuron differentiation disrupted, abnormal	WT + MO1-olig2	standard conditions	Fig. 5 from Park et al., 2002
spinal cord lacks parts or has fewer parts of type oligodendrocyte, abnormal	WT + MO1-olig2	standard conditions	Fig. 6 from Park et al., 2002
spinal cord lacks all parts of type primary motor neuron, abnormal	WT + MO1-olig2	standard conditions	Fig. 5 from Park et al., 2002
dopaminergic neuron decreased amount, abnormal	WT + MO1-olig2	standard conditions	Fig. 5 from Borodovsky et al., 2009
oligodendrocyte development disrupted, abnormal	WT + MO1-olig2	standard conditions	Fig. 8 from Schebesta et al., 2009 Fig. 6 from Park et al., 2002

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Citations

Include unpublished citations

Tsai, T.Y., Sikora, M., Xia, P., Colak-Champollion, T., Knaut, H., Heisenberg, C.P., Megason, S.G. (2020) An adhesion code ensures robust pattern formation during tissue morphogenesis. Science (New York, N.Y.). 370:113-116
Lim, A.H., Suli, A., Yaniv, K., Weinstein, B., Li, D.Y., and Chien, C.B. (2011) Motoneurons are essential for vascular pathfinding. Development (Cambridge, England). 138(17):3847-3857
Borodovsky, N., Ponomaryov, T., Frenkel, S., and Levkowitz, G. (2009) Neural protein Olig2 acts upstream of the transcriptional regulator sim1 to specify diencephalic dopaminergic neurons. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(4):826-834
Schebesta, M., and Serluca, F.C. (2009) olig1 expression identifies developing oligodendrocytes in zebrafish and requires hedgehog and notch signaling. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(4):887-898
Bae, Y.K., Shimizu, T., and Hibi, M. (2005) Patterning of proneuronal and inter-proneuronal domains by hairy- and enhancer of split-related genes in zebrafish neuroectoderm. Development (Cambridge, England). 132(6):1375-1385
Lewis, K.E., Bates, J., and Eisen, J.S. (2005) Regulation of iro3 expression in the zebrafish spinal cord. Developmental Dynamics : an official publication of the American Association of Anatomists. 232(1):140-148
Park, H.-C., Mehta, A., Richardson, J.S., and Appel, B. (2002) olig2 is required for zebrafish primary motor neuron and oligodendrocyte development. Developmental Biology. 248(2):356-368

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