KBP regulates the speed of axonal outgrowth in the CNS. (A-A″) Lateral views from a time-lapse series of the ventral spinal cord of a wild-type embryo with axons labeled by the Tg(HuC:kaede) transgene at 36 (A), 38 (A′) and 40 hpf (A″). Anterior is towards the left and dorsal is towards the top. The arrowheads and red dots indicate the posterior-most axons. (B-B″) Lateral views from a time-lapse series of the ventral spinal cord of a kbpst23 mutant embryo with axons labeled by the Tg(HuC:kaede) transgene at 36 (B), 38 (B′) and 40 hpf (B″). Anterior is towards the left and dorsal is towards the top. The arrowheads and blue dots indicate the posteriormost axons.
|