FIGURE

Fig. 7

ID

ZDB-FIG-080211-40

Publication

Lyons et al., 2008 - KBP is essential for axonal structure, outgrowth and maintenance in zebrafish, providing insight into the cellular basis of Goldberg-Shprintzen syndrome

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Fig. 7

KBP is required for microtubule organization, localization of axonal mitochondria and synaptic vesicles, and axonal maintenance in the PNS. (A,B) TEM images of transverse sections through the PLLn at 30 hpf shows more organized microtubules (black arrowheads) in wild-type (A) axons than in kbp^st23 mutant (B) axons and disorganized microtubules (white arrowheads) in kbp^st23 mutant (B) axons. Scale bars: 200 nm. (C,D) TEM images of longitudinal sections through the PLLn at 50 hpf show more profiles of properly oriented microtubules (arrowheads) running parallel to the long axis of the axon in wild type (C) than in the kbp^st23 mutant (D). White arrow indicates an accumulation of synaptic vesicles in a kbp^st23 mutant axon. Scale bars: 0.5 μm. (E,F) TEM images of transverse sections through the PLLn at 72 hpf show more myelinated axons (black asterisks) and mitochondria within axons (white arrowheads) in the wild type (E) than in the kbp^st23 mutant. White asterisks in F indicate myelinated axons undergoing degeneration. Scale bars: 0.5 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	kifbp^st23/st23
Observed In:	microtubule cytoskeleton organization neuron microtubule cytoskeleton posterior lateral line nerve posterior lateral line nerve axon posterior lateral line nerve mitochondrion posterior lateral line nerve synaptic vesicle
Stage Range:	Prim-15 to Protruding-mouth

Phenotype Detail

Acknowledgments

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