FIGURE

Fig. 5

ID

ZDB-FIG-080211-38

Publication

Lyons et al., 2008 - KBP is essential for axonal structure, outgrowth and maintenance in zebrafish, providing insight into the cellular basis of Goldberg-Shprintzen syndrome

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Fig. 5

KBP is required to maintain the speed of axonal outgrowth in the PNS. (A-A″) Lateral views from a time-lapse series of a wild-type embryo with PLLn axons labeled by the Tg(HuC:kaede) transgene at 36 (A), 37 (A′) and 38 hpf (A″). Anterior is towards the left and dorsal is towards the top. The arrowheads indicate the posteriormost axons. (B-B″) Lateral views from a time-lapse series of a kbp^st23 mutant embryo with PLLn axons labeled by the Tg(HuC:kaede) transgene at 36 (B), 37 (B′) and 38 hpf (B″). Anterior is towards the left and dorsal is towards the top. The arrowheads indicate the posteriormost axons. (C-C″) Lateral views from a time-lapse series of a kbp^st23 mutant embryo with PLLn axons labeled by the Tg(HuC:kaede) transgene at 54 (C), 55 (C′) and 56 hpf (C″). Anterior is towards the left and dorsal is towards the top. The arrowheads indicate the posteriormost axons. (D-D″) Lateral views from a time-lapse series of a kbp^st23 mutant embryo with PLLn axons labeled by the Tg(HuC:kaede) transgene at 57 (D), 58 (D′) and 60 hpf (D″). Anterior is towards the left and dorsal is towards the top. Arrowheads indicate an axonal swelling that moves backwards along the nerve.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	kifbp^st23/st23; rw0130aTg
Observed In:	efferent axon development in a lateral line nerve posterior lateral line nerve
Stage:	Prim-25

Phenotype Detail

Acknowledgments

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