FIGURE

Fig. 3

ID

ZDB-FIG-080211-36

Publication

Lyons et al., 2008 - KBP is essential for axonal structure, outgrowth and maintenance in zebrafish, providing insight into the cellular basis of Goldberg-Shprintzen syndrome

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Fig. 3

KBP is required for axonal development. Lateral views of PLLn axons in live embryos bearing the Tg(HuC:kaede) transgene at 56 hpf. The images show the segment of the nerve corresponding to about somites 10-16. Axons of the wild type (A) have advanced further posterior than those in the kbp^st23 mutant (B). Axonal outgrowth is rescued in kbp^st23 mutants injected with full-length wild-type kbp mRNA (C) and the mut2 kbp mRNA (E), but not in kbp^st23 mutants injected with the mut1 kbp mRNA (D). Wild-type embryos injected with 2.4 ng of kbp morpholino (F) resemble kbp^st23 mutants. In all images, anterior is towards the left and dorsal is towards the top.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	rw0130aTg + MO1-kifbp kifbp^st23/st23; rw0130aTg
Knockdown Reagent:	MO1-kifbp
Observed In:	efferent axon development in posterior lateral line nerve posterior lateral line nerve
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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