FIGURE

Fig. 4

ID

ZDB-FIG-070219-21

Publication

Millimaki et al., 2007 - Zebrafish atoh1 genes: classic proneural activity in the inner ear and regulation by Fgf and Notch

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Fig. 4

Interactions between atoh1 and the Delta-Notch pathway. (A,B) Expression of dlA at 22 hpf in a control embryo (A) and atoh1a morphant (B). (C-F) Expression of dlD at 14 hpf in a control embryo (C), atoh1b morphant (D), mib mutant (E) and mib mutant-atoh1b morphant (F). (G,H) mib mutants show expanded otic domains of atoh1b (G) and atoh1a (H) at 14 hpf. (I,J) Pax2 antibody staining at 32 hpf reveals supernumerary hair cells in a mib mutant (I) but no hair cells in a mib mutant co-injected with atoh1a MO and atoh1b MO (J). Arrowheads and arrows indicate otic regions. All images are dorsolateral views with anterior to the left. Scale bars: 30 μm in A,E,I-P; 15 μm in B-D,F-H.

Expression Data

Genes:	atoh1a atoh1b dla dld
Fish:	AB mib1^ta52b/ta52b AB + MO1-atoh1b AB + MO4-atoh1a mib1^ta52b/ta52b + MO1-atoh1b
Knockdown Reagents:	MO1-atoh1b MO4-atoh1a
Anatomical Terms:	otic placode otic vesicle
Stage Range:	10-13 somites to 26+ somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mib1^ta52b/ta52b + MO1-atoh1b + MO4-atoh1a
Knockdown Reagents:	MO1-atoh1b MO4-atoh1a
Observed In:	hair cell
Stage Range:	10-13 somites to Prim-15

Phenotype Detail

Acknowledgments

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