ZFIN ID: ZDB-FIG-061110-2
Alt et al., 2006 - Arteries define the position of the thyroid gland during its developmental relocalisation. Development (Cambridge, England)   133(19):3797-3804 Full text @ Development
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Fish:
Knockdown Reagents:
Anatomical Terms:
Stage: Long-pec

Fig. 2 Mutants with defects in ventral aorta development show correlating thyroid abnormalities. (A-H) Frontal views, showing vasculature (tie1 expression) or thyroid (nk2.1a expression). Control morpholino injected embryos are indistinguishable from wild-type embryos or kdry17 siblings. (I-L) Sections showing folliclular lumen (thyroglobulin immunostaining, brown) in relation to endothelial cells (tie1 expression, blue). (M-P) At 120 hpf, thyroid follicles (T4 immunostaining, brown) fail to align along the ventral aorta. In F-H,J-L the thyroid appears larger owing to the lateral expansion. However, in wild-type embryos the thyroid extends along the AP axis (compare with Fig. 1B). Concomitant with lateral expansion, its AP extent appears to be reduced, so that the size remains similar. This is also reflected by normal follicle numbers at 120 hpf (M-P). TG, thyroglobulin; Thyr, thyroid; Vasc, vasculature; va, ventral aorta; 1st, first pair of branchial arteries.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
nkx2.4b WT + MO2-vegfaa standard conditions Long-pec thyroid primordium ISH
WT + MO4-tal1 standard conditions Long-pec thyroid primordium ISH
kdrly17/y17 standard conditions Long-pec thyroid primordium ISH
tie1 WT + MO2-vegfaa standard conditions Long-pec pharyngeal vasculature ISH
WT + MO4-tal1 standard conditions Long-pec pharyngeal vasculature ISH
kdrly17/y17 standard conditions Long-pec pharyngeal vasculature ISH
Antibody Labeling Details No data available
Phenotype Details No data available
Acknowledgments:
ZFIN wishes to thank the journal Development (Cambridge, England) for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Development