Gene

nkx2.4b

ID
ZDB-GENE-000830-1
Name
NK2 homeobox 4b
Symbol
nkx2.4b Nomenclature History
Previous Names
  • nk2.1a (1)
  • nkx2.1 (1)
  • nkx2.1a
  • nkx2.4a (1)
  • titf1
  • titf1a (1)
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in hypothalamus development and thyroid gland development. Predicted to localize to nucleus. Is expressed in several structures, including endocrine system; forebrain; neural keel; neural plate; and swim bladder. Orthologous to human NKX2-4 (NK2 homeobox 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
79 figures from 50 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nkx2.4b Human Ortholog
No data available
Associated With nkx2.4b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeodomain
Domain IPR020479 Homeodomain, metazoa
Family IPR050394 Homeobox NK-like transcription regulators
Homologous_superfamily IPR009057 Homedomain-like superfamily
Domain Details Per Protein
Protein Length Homedomain-like superfamily Homeobox, conserved site Homeobox NK-like transcription regulators Homeodomain Homeodomain, metazoa
UniProtKB:Q9I8L7 307
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA nkx2.4b-201 (1) Ensembl 1,151 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations