ZFIN ID: ZDB-GENE-000830-1
Gene Name: NK2 homeobox 4b
Gene Symbol: nkx2.4b    Nomenclature History

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Previous Names: nk2.1a (1), nkx2.1 (1), nkx2.1a, nkx2.4a (1), titf1, titf1a (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in hypothalamus development and thyroid gland development. Predicted to localize to nucleus. Is expressed in several structures, including endocrine system; forebrain; neural keel; neural plate; and swim bladder. Orthologous to human NKX2-4 (NK2 homeobox 4).
Genome Resources: Alliance (1),  Gene:58112 (1),  Ensembl(GRCz11):ENSDARG00000104107 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa23811 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-nkx2.4b
    1
    CRISPR2-nkx2.4b
    1
    MO1-nkx2.4b N/A 3
    MO2-nkx2.4b N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH nkx2.4b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH nkx2.4b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process hypothalamus development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nkx2.4b-201 (1)    Ensembl 1151
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nkx2.4b No data available
    MARKER RELATIONSHIPS
    nkx2.4b Contained in: [BAC] DKEY-165F9 (1) (order this)
    nkx2.4b Encodes: [cDNA] MGC:193896 (1), MGC:193913 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131589 (1) 1175 nt
    Genomic GenBank:CT573061 (1) 79800 nt
    Select Tool
    Polypeptide UniProtKB:A5WVY6 (1) 307 aa
    Sequence Information (all 18)
    ORTHOLOGY for nkx2.4b ( Chr: 20 )
    CITATIONS (110)