PUBLICATION

Arteries define the position of the thyroid gland during its developmental relocalisation

Authors
Alt, B., Elsalini, O.A., Schrumpf, P., Haufs, N., Lawson, N.D., Schwabe, G.C., Mundlos, S., Gruters, A., Krude, H., and Rohr, K.B.
ID
ZDB-PUB-060921-14
Date
2006
Source
Development (Cambridge, England)   133(19): 3797-3804 (Journal)
Registered Authors
Alt, Burkhard, Elsalini, Osama, Lawson, Nathan, Rohr, Klaus
Keywords
Thyroid, Zebrafish, Mouse, Arteries, Vegf, Scl, Hedgehog
MeSH Terms
  • Morphogenesis*/genetics
  • Zebrafish/embryology*
  • Zebrafish/genetics
  • Endothelium, Vascular/embryology
  • Mutation
  • Mice, Mutant Strains
  • Mice/embryology*
  • Mice/genetics
  • Aorta, Abdominal/embryology*
  • Carotid Arteries/embryology*
  • Embryonic Development
  • Hedgehog Proteins/genetics
  • Thyroid Gland/anatomy & histology
  • Thyroid Gland/blood supply*
  • Thyroid Gland/embryology*
  • Animals
(all 16)
PubMed
16968815 Full text @ Development
Abstract
During vertebrate development, the thyroid gland undergoes a unique relocalisation from its site of induction to a distant species-specific position in the cervical mesenchyme. We have analysed thyroid morphogenesis in wild-type and mutant zebrafish and mice, and find that localisation of growing thyroid tissue along the anteroposterior axis in zebrafish is linked to the development of the ventral aorta. In grafting experiments, ectopic vascular cells influence the localisation of thyroid tissue cell non-autonomously, showing that vessels provide guidance cues in zebrafish thyroid morphogenesis. In mouse thyroid development, the midline primordium bifurcates and two lobes relocalise cranially along the bilateral pair of carotid arteries. In hedgehog-deficient mice, thyroid tissue always develops along the ectopically and asymmetrically positioned carotid arteries, suggesting that, in mice (as in zebrafish), co-developing major arteries define the position of the thyroid. The similarity between zebrafish and mouse mutant phenotypes further indicates that thyroid relocalisation involves two morphogenetic phases, and that variation in the second phase accounts for species-specific differences in thyroid morphology. Moreover, the involvement of vessels in thyroid relocalisation sheds new light on the interpretation of congenital thyroid defects in humans.
Genes / Markers
Figures
Figure Gallery (5 images)
Show all Figures
Expression
Phenotype
No data available
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
s5
    		Point Mutation
    y17
      		Point Mutation
      1 - 2 of 2
      Show
      Human Disease / Model
      No data available
      Sequence Targeting Reagents
      Target Reagent Reagent Type
      tal1MO4-tal1MRPHLNO
      tnnt2aMO1-tnnt2aMRPHLNO
      vegfaaMO2-vegfaaMRPHLNO
      1 - 3 of 3
      Show
      Fish
      Fish
      kdrly17/y17
      npas4ls5
      WT
      WT + MO2-vegfaa
      WT + MO4-tal1
      1 - 5 of 5
      Show
      Antibodies
      No data available
      Orthology
      No data available
      Engineered Foreign Genes
      No data available
      Mapping
      No data available
      Your Input Welcome
      We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.
      Citation
      Alt, B., Elsalini, O.A., Schrumpf, P., Haufs, N., Lawson, N.D., Schwabe, G.C., Mundlos, S., Gruters, A., Krude, H., and Rohr, K.B. (2006) Arteries define the position of the thyroid gland during its developmental relocalisation. Development (Cambridge, England). 133(19):3797-3804.