Gene

tie1

ID
ZDB-GENE-990415-55
Name
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Symbol
tie1 Nomenclature History
Previous Names
  • tie-1
  • sb:eu718
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have transmembrane receptor protein tyrosine kinase activity. Involved in blood vessel development; endothelial cell-cell adhesion; and heart development. Predicted to localize to integral component of plasma membrane and receptor complex. Is expressed in several structures, including angioblastic mesenchymal cell; cardiovascular system; intermediate cell mass of mesoderm; pharyngeal arch; and ventral mesoderm. Orthologous to human TIE1 (tyrosine kinase with immunoglobulin like and EGF like domains 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
62 figures from 38 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tie1 Human Ortholog
No data available
Associated With tie1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR000742 EGF-like domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR003599 Immunoglobulin subtype
Domain IPR003961 Fibronectin type III
Domain IPR007110 Immunoglobulin-like domain
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036116 Fibronectin type III superfamily
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Domain Details Per Protein
Protein Length EGF-like domain Fibronectin type III Fibronectin type III superfamily Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain
UniProtKB:A0A2R8QM04 1027
UniProtKB:O73792 184
UniProtKB:G1K2H0 1122
UniProtKB:A0A2R8QE85 1116
UniProtKB:A0A2R8Q3T0 1144
UniProtKB:A0A2R8Q2A9 1150
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations