FIGURE

Fig. 6

ID

ZDB-FIG-050930-14

Publication

Babb et al., 2005 - Zebrafish R-cadherin (Cdh4) controls visual system development and differentiation

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Fig. 6

Expression of early markers of photoreceptor identity is reduced in cdh4 morphants. A-F: Zebrafish embryos were injected with either standard control morpholino oligonucleotide (MO, A,D) or cdh4 MO (B,C,E,F). crx (A-C) and otx5 (D-F) labeling in 78 hours postfertilization (hpf), embryos were used as markers of photoreceptor specification and differentiation. A,D: In controls, crx and otx5 labeling were confined to the photoreceptor layer and the outermost part of the inner nuclear layer. B,E: Some reduction of staining was seen in slightly affected cdh4 morphants. C,F: In severe cdh4 morphants, both crx and otx5 staining were reduced and lacked defined laminae.

Expression Data

Genes:	crx otx5
Fish:	WT WT + MO1-cdh4
Knockdown Reagent:	MO1-cdh4
Anatomical Terms:	retinal inner nuclear layer retinal photoreceptor layer
Stage:	Protruding-mouth

Expression Detail

Gene	Fish	Conditions	Stage	Anatomy	Assay
crx	WT	standard conditions	Protruding-mouth	retinal inner nuclear layer	ISH
crx	WT	standard conditions	Protruding-mouth	retinal photoreceptor layer	ISH
crx	WT + MO1-cdh4	standard conditions	Protruding-mouth	retinal inner nuclear layer	ISH
crx	WT + MO1-cdh4	standard conditions	Protruding-mouth	retinal photoreceptor layer	ISH
otx5	WT	standard conditions	Protruding-mouth	retinal inner nuclear layer	ISH
otx5	WT	standard conditions	Protruding-mouth	retinal photoreceptor layer	ISH
otx5	WT + MO1-cdh4	standard conditions	Protruding-mouth	retinal inner nuclear layer	ISH
otx5	WT + MO1-cdh4	standard conditions	Protruding-mouth	retinal photoreceptor layer	ISH

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Antibody Labeling

Phenotype Data

Fish:	WT + MO1-cdh4 WT + MO2-cdh4
Knockdown Reagents:	MO1-cdh4 MO2-cdh4
Observed In:	photoreceptor cell differentiation retina layer formation
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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