Gene
crx
- ID
- ZDB-GENE-010403-1
- Name
- cone-rod homeobox
- Symbol
- crx Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Enables DNA binding activity. Acts upstream of or within eye photoreceptor cell development; negative regulation of retinal cell programmed cell death; and visual perception. Predicted to be active in nucleus. Is expressed in forebrain; immature eye; neuroepithelial cell; photoreceptor cell; and visual system. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 7 and cone-rod dystrophy 2. Orthologous to human ARGFX (arginine-fifty homeobox); CRX (cone-rod homeobox); and DPRX (divergent-paired related homeobox).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 71 figures from 46 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu68 (10 images)
- eu16 (7 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cone-rod dystrophy 2 | Alliance | Cone-rod retinal dystrophy-2 | 120970 |
| Leber congenital amaurosis 7 | Alliance | Leber congenital amaurosis 7 | 613829 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Transcription factor Otx | Transcription factor Otx, C-terminal |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q8JIZ3 | InterPro | 281 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-crx | polyclonal | Rabbit |
|
Research Genetics, Inc.
|
3 |
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(crx:EGFP) |
|
| 1 | Chiang et al., 2024 | |
| Tg(crx:EGFP-2A-crb2a_delEX) |
|
| 1 | Lin et al., 2020 | |
| Tg(crx:EGFP-2A-FLAG-foxq2) |
|
| 3 | Ogawa et al., 2021 | |
| Tg(crx:EGFP-2A-FLAG-six6b) |
|
| 2 | Ogawa et al., 2019 | |
| Tg(crx:EGFP-2A-six7-FLAG) |
|
| 1 | Ogawa et al., 2019 | |
| Tg(crx:EGFP-CAAX,myl7:GFP) |
|
| 1 | Aparicio et al., 2021 | |
| Tg(crx:EGFP-mak) |
|
| 1 | Chiang et al., 2024 | |
| Tg(crx:EGFP-mak_K32A) |
|
| 1 | Chiang et al., 2024 | |
| Tg(crx:EGFP-mak_K32A_T157A_Y159F) |
|
| 1 | Chiang et al., 2024 | |
| Tg(crx:EGFP-mak_T157A_Y159F) |
|
| 1 | Chiang et al., 2024 |
1 - 10 of 19
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-46E8 | ZFIN Curated Data | |
| Encodes | EST | eu16 | Thisse et al., 2005 | |
| Encodes | EST | eu68 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:73334 | ZFIN Curated Data |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_152940 (1) | 2385 nt | ||
| Genomic | GenBank:BX510647 (1) | 198695 nt | ||
| Polypeptide | UniProtKB:Q8JIZ3 (1) | 281 aa |
- Chiang, H.J., Nishiwaki, Y., Chiang, W.C., Masai, I. (2024) Male germ cell-associated kinase (MAK) is required for axoneme formation during ciliogenesis in zebrafish photoreceptors. Disease models & mechanisms. 17(7):
- Jing, Y., Luo, Y., Li, L., Liu, M., Liu, J.X. (2024) Deficiency of copper responsive gene stmn4 induces retinal developmental defects. Cell biology and toxicology. 40:22
- Neil, G.J., Kluttig, K.H., Allison, W.T. (2024) Determining Photoreceptor Cell Identity: Rod Versus Cone Fate Governed by tbx2b Opposing nrl. Investigative ophthalmology & visual science. 65:3939
- Volkov, L.I., Ogawa, Y., Somjee, R., Vedder, H.E., Powell, H.E., Poria, D., Meiselman, S., Kefalov, V.J., Corbo, J.C. (2024) Samd7 represses short-wavelength cone genes to preserve long-wavelength cone and rod photoreceptor identity. Proceedings of the National Academy of Sciences of the United States of America. 121:e2402121121e2402121121
- Wang, W., Yang, N., Wang, L., Zhu, Y., Chu, X., Xu, W., Li, Y., Xu, Y., Gao, L., Zhang, B., Zhang, G., Sun, Q., Wang, W., Wang, Q., Zhang, W., Chen, D. (2024) The TET-Sall4-BMP regulatory axis controls craniofacial cartilage development. Cell Reports. 43:113873113873
- Sun, K., Han, Y., Li, J., Yu, S., Huang, Y., Zhang, Y., Reilly, J., Tu, J., Gao, P., Jia, D., Chen, X., Hu, H., Ren, M., Li, P., Luo, J., Ren, X., Zhang, X., Shu, X., Liu, F., Liu, M., Tang, Z. (2023) The splicing factor DHX38 enables retinal development through safeguarding genome integrity. iScience. 26:108103108103
- Agostini, C., Bühler, A., Antico Calderone, A., Aadepu, N., Herder, C., Loosli, F., Carl, M. (2022) Conserved and diverged asymmetric gene expression in the brain of teleosts. Frontiers in cell and developmental biology. 10:1005776
- Carstensen, M.B., Medvetzky, A., Weinberger, A., Driever, W., Gothilf, Y., Rath, M.F. (2022) Genetic ablation of the Bsx homeodomain transcription factor in zebrafish: Impact on mature pineal gland morphology and circadian behavior. Journal of pineal research. 72(4):e12795
- Jin, M., Zhang, H., Xu, B., Li, Y., Qin, H., Yu, S., He, J. (2022) Jag2b-Notch3/1b-mediated neuron-to-glia crosstalk controls retinal gliogenesis. EMBO reports. 23(10):e54922
- Aparicio, G., Rodao, M., Badano, J.L., Zolessi, F.R. (2021) Photoreceptor progenitor dynamics in the zebrafish embryo retina and its modulation by primary cilia and N-cadherin. The International journal of developmental biology. 65:439-455
1 - 10 of 110
Show