Gene

otx5

ID
ZDB-GENE-030508-1
Name
orthodenticle homolog 5
Symbol
otx5 Nomenclature History
Previous Names
  • cb828 (1)
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Exhibits sequence-specific DNA binding activity. Involved in circadian regulation of gene expression and positive regulation of transcription, DNA-templated. Predicted to localize to nucleus. Is expressed in forebrain; optic vesicle; and visual system. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 7 and cone-rod dystrophy 2. Orthologous to human CRX (cone-rod homeobox).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
79 figures from 51 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With otx5 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
cone-rod dystrophy 2 Alliance Cone-rod retinal dystrophy-2 120970
Leber congenital amaurosis 7 Alliance Leber congenital amaurosis 7 613829
Associated With otx5 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeobox domain
Domain IPR013851 Transcription factor Otx, C-terminal
Family IPR003025 Transcription factor Otx
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Domain Details Per Protein
Protein Length Homeobox, conserved site Homeobox domain Homeobox-like domain superfamily Transcription factor Otx Transcription factor Otx, C-terminal
UniProtKB:Q6NYT9 289
UniProtKB:F1R982 289
UniProtKB:Q8UUZ5 289
UniProtKB:Q6PH22 289
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations