Research
General Information
ZIRC
ZFIN: Gene: ptc1
ZFIN ID: ZDB-GENE-980526-44

Gene Name:patched 1
Gene Symbol: ptc1
Previous Names: etID309849.2(1) , ptc-1, blw(1) , blowout(1)
Nomenclature History


GENE EXPRESSION:(current status)
All expression data: 83 figure(s) from 58 publications
Directly submitted expression data: 6 figure(s) (12 images) from Thisse et al., 2005 [eu467]
Wild Type Stages, Structures: Gastrula:90%-epiboly (9.00h-10.00h) to Larval:Day 6 (144.00h-168.00h)
  adaxial cell, axis ... (all 36)
Curated microarray expression: GEO  (1)

MUTANTS AND TARGETED KNOCKDOWNS:
Mutant line(s):   9 genotypes
Allele(s):   hu1602, tc294z
Phenotype: (current status)
  Data: 8 figures from 3 publications
  Observed in: axon, brain, eye, lens, mandibular arch skeleton ... (all 21)
Knockdown reagents: MO1-ptc1 (1) ,   MO2-ptc1 (1)

GENE PRODUCTS:

Gene Ontology
Ontology GO Term
Molecular Function hedgehog receptor activity (more)
Biological Process cardioblast differentiation (more)
Cellular Component integral to membrane (more)
All GO Terms (8)

Protein Families, Domains and Sites:
  • InterPro:IPR000731 (1)
  • InterPro:IPR003392 (1)
  • InterPro:IPR004766 (1)
  • PROSITE:PS50156 (1)
  • Pfam:PF02460 (1)
  • Loading Transcript Data...

    Gene Product Description


    SEGMENT (CLONE AND PROBE) RELATIONSHIPS:
    ptc1 Contained in [BAC] CH211-226H23 (1)    (order this)
    ptc1 Encodes [EST] eu467 (1)
    [cDNA] MGC:162571 (1)    (order this)

    SEQUENCE INFORMATION:
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_130988 (1) 3672 bp
    Genomic GenBank:BX649493 (1) 175551 bp
    Polypeptide UniProtKB:Q98864 (1) 1220 aa
    Sequence Clusters UniGene:75755 (1)
    All Sequence Information (11)

    OTHER  ptc1  GENE / MARKER PAGES:

  • Entrez Gene:30181 (1)
  • VEGA:OTTDARG00000019874 (1)
  • Ensembl(Zv8):ENSDARG00000055026 (1)

  • MAPPING INFORMATION:
      LG:  2    Details   View Map: Merged  Individual Panels

    ORTHOLOGY:
      Evidence
    Species Symbol Chromosome (Position) Accession # AA CL
    Zebrafish ptc1  2
    Human PTCH2  1 (p33-p34)
  • OMIM:603673
  • Entrez Gene:8643
  • Mouse Ptch2  4 (56.50 cM)
  • MGI:1095405
  • Entrez Gene:19207
  • Orthology Details

    CITATIONS   (109)