Gene

cacna1da

ID

ZDB-GENE-030616-135

Name

calcium channel, voltage-dependent, L type, alpha 1D subunit, a

Symbol

cacna1da Nomenclature History

Previous Names

cacna1d (1)
cav1.3a (1)
gem
gemini
si:dz136d19.3
si:dz223c6.1

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to have high voltage-gated calcium channel activity. Involved in detection of mechanical stimulus involved in sensory perception of sound; neuromuscular process controlling balance; and synapse organization. Localizes to basal plasma membrane and ribbon synapse. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Is expressed in central nervous system; heart; and neuromast. Orthologous to human CACNA1D (calcium voltage-gated channel subunit alpha1 D).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

13 figures from 9 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 8 figures from 6 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cacna1da Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Primary aldosteronism, seizures, and neurologic abnormalities	615474
		Sinoatrial node dysfunction and deafness	614896

Associated With cacna1da Via Experimental Models

Human Disease	Fish	Conditions	Citations
schizophrenia	cacna1da^sa17298/+	standard conditions	Banono et al., 2020

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR005821	Ion transport domain
Domain	IPR014873	Voltage-dependent calcium channel, alpha-1 subunit, IQ domain
Domain	IPR031649	Voltage-dependent L-type calcium channel, IQ-associated domain
Domain	IPR031688	Voltage-gated calcium channel subunit alpha, C-terminal
Family	IPR002077	Voltage-dependent calcium channel, alpha-1 subunit
Family	IPR005446	Voltage-dependent calcium channel, L-type, alpha-1 subunit
Family	IPR050599	Voltage-dependent calcium channel alpha-1 subunit
Homologous_superfamily	IPR027359	Voltage-dependent channel domain superfamily

Domain Details Per Protein

Protein	Length	Ion transport domain	Voltage-dependent calcium channel alpha-1 subunit	Voltage-dependent calcium channel, alpha-1 subunit	Voltage-dependent calcium channel, alpha-1 subunit, IQ domain	Voltage-dependent calcium channel, L-type, alpha-1 subunit	Voltage-dependent channel domain superfamily	Voltage-dependent L-type calcium channel, IQ-associated domain	Voltage-gated calcium channel subunit alpha, C-terminal
UniProtKB:A0A8M9Q745 InterPro	2054
UniProtKB:A0A8M9QHK6 InterPro	2068
UniProtKB:A0A8M9QLJ7 InterPro	2082
UniProtKB:A0A8M9QD08 InterPro	2057
UniProtKB:A0A8M9QHK0 InterPro	2093
UniProtKB:A0A8M9QD03 InterPro	2084
UniProtKB:A0A8M9PUS4 InterPro	2093
UniProtKB:A0A8M9Q738 InterPro	2092
UniProtKB:Q6QRQ2 InterPro	2082
UniProtKB:A0A8M9PUS9 InterPro	2068

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	cacna1da-201 (1) Ensembl	Ensembl	6,504 nt	Select Tool ZFIN BLAST
mRNA	cacna1da-202 (1) Ensembl	Ensembl	6,421 nt	Select Tool
mRNA	cacna1fb-207 (1) Ensembl	Ensembl	6,662 nt	Select Tool
mRNA	ottdart00000001787 (1)	Havana	2,432 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ottdart00000001972 (1)	Havana	4,125 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-cacna1da	polyclonal	cacna1da		Rabbit	IHC		9

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations