Gene
cacna1da
- ID
- ZDB-GENE-030616-135
- Name
- calcium channel, voltage-dependent, L type, alpha 1D subunit, a
- Symbol
- cacna1da Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable high voltage-gated calcium channel activity. Acts upstream of or within detection of mechanical stimulus involved in sensory perception of sound; neuromuscular process controlling balance; and synapse organization. Located in basal plasma membrane and ribbon synapse. Is expressed in central nervous system; heart; and neuromast. Used to study schizophrenia. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human CACNA1D (calcium voltage-gated channel subunit alpha1 D).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
schizophrenia | cacna1dasa17298/+ | standard conditions | Banono et al., 2020 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR005821 | Ion transport domain |
Domain | IPR014873 | Voltage-dependent calcium channel, alpha-1 subunit, IQ domain |
Domain | IPR031649 | Voltage-dependent L-type calcium channel, IQ-associated domain |
Domain | IPR031688 | Voltage-gated calcium channel subunit alpha, C-terminal |
Family | IPR002077 | Voltage-dependent calcium channel, alpha-1 subunit |
Family | IPR005446 | Voltage-dependent calcium channel, L-type, alpha-1 subunit |
Homologous_superfamily | IPR027359 | Voltage-dependent channel domain superfamily |
Domain Details Per Protein
Protein | Length | Ion transport domain | Voltage-dependent calcium channel, alpha-1 subunit | Voltage-dependent calcium channel, alpha-1 subunit, IQ domain | Voltage-dependent calcium channel, L-type, alpha-1 subunit | Voltage-dependent channel domain superfamily | Voltage-dependent L-type calcium channel, IQ-associated domain | Voltage-gated calcium channel subunit alpha, C-terminal |
---|---|---|---|---|---|---|---|---|
UniProtKB:B3DK08
|
2068 | |||||||
UniProtKB:A0A0R4IK24
|
2068 | |||||||
UniProtKB:A0A0R4IQX8
|
2082 | |||||||
UniProtKB:Q8JFR2
|
809 | |||||||
UniProtKB:Q7ZZ58
|
1374 | |||||||
UniProtKB:Q6QRQ2
|
2082 |
Type | Name | Length (nt) | Analysis |
---|---|---|---|
mRNA |
cacna1da-202
(1)
|
5981 nt | |
mRNA |
cacna1fb-207
(1)
|
6662 nt | |
mRNA | ottdart00000001787 (1) | 2432 nt | |
mRNA | ottdart00000001972 (1) | 4125 nt |
Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
Ab1-cacna1da | polyclonal | Rabbit |
|
9 |
Plasmids
No data available