Gene

vwf

ID

ZDB-GENE-070103-1

Name

von Willebrand factor

Symbol

vwf Nomenclature History

Previous Names

si:ch1073-474e24.1

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to be an extracellular matrix structural constituent. Acts upstream of or within hemostasis. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including ball; head; intestinal epithelium; post-vent vasculature; and thrombocyte. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; Bernard-Soulier syndrome; end stage renal disease; essential thrombocythemia; and von Willebrand's disease (multiple). Orthologous to human VWF (von Willebrand factor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Carrillo et al., 2010
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With vwf Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
von Willebrand's disease 1	Alliance	von Willebrand disease, type 1	193400
von Willebrand's disease 2	Alliance	von Willebrand disease, types 2A, 2B, 2M, and 2N	613554
von Willebrand's disease 3	Alliance	von Willebrand disease, type 3	277480

Associated With vwf Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001007	VWFC domain
Domain	IPR001846	von Willebrand factor, type D domain
Domain	IPR002035	von Willebrand factor, type A
Domain	IPR002919	Trypsin Inhibitor-like, cysteine rich domain
Domain	IPR006207	Cystine knot, C-terminal
Domain	IPR014853	VWF/SSPO/Zonadhesin-like, cysteine-rich domain
Family	IPR050780	Mucin/von Willebrand/Thrombospondin superfamily
Homologous_superfamily	IPR036084	Serine protease inhibitor-like superfamily
Homologous_superfamily	IPR036465	von Willebrand factor A-like domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length	Cystine knot, C-terminal	Mucin/von Willebrand/Thrombospondin superfamily	Serine protease inhibitor-like superfamily	Trypsin Inhibitor-like, cysteine rich domain	von Willebrand factor A-like domain superfamily	von Willebrand factor, type A	von Willebrand factor, type D domain	VWFC domain	VWF/SSPO/Zonadhesin-like, cysteine-rich domain
UniProtKB:E7F9Z1	InterPro	2812

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	vwf-201 (1) Ensembl	Ensembl	8,713 nt	Select Tool ZFIN BLAST
mRNA	vwf-202 (1) Ensembl	Ensembl	6,177 nt	Select Tool ZFIN BLAST
mRNA	vwf-204 (1) Ensembl	Ensembl	1,332 nt	Select Tool ZFIN BLAST
ncRNA	vwf-003 (1) Ensembl	Ensembl	823 nt	Select Tool ZFIN BLAST
ncRNA	vwf-004 (1) Ensembl	Ensembl	823 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-vwf	polyclonal	vwf			IHC	Sigma-Aldrich	1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations