Gene
she
- ID
- ZDB-GENE-090915-6
- Name
- Src homology 2 domain containing E
- Symbol
- she Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable phosphotyrosine residue binding activity. Is expressed in several structures, including blood vessel; hindbrain; lateral line primordium; post-vent region; and vascular cord. Orthologous to human SHE (Src homology 2 domain containing E).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ci26 | Allele with one deletion | Unknown | Unknown | TALEN | |
| ci30 | Allele with one delins | Unknown | Unknown | CRISPR | |
| la019634Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa28648 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-she | Schumacher et al., 2024 | |
| CRISPR2-she | Schumacher et al., 2024 | |
| TALEN1-she | Schumacher et al., 2024 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | SH2 domain | SH2 domain-containing adapter proteins | SH2 domain superfamily | SHE, SH2 domain |
|---|---|---|---|---|---|---|
| UniProtKB:E7F7N7 | InterPro | 438 |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(fli1:she-2A-mCherry) |
| 1 | Schumacher et al., 2024 | ||
| Tg(hsp70l:she-2A-mCherry,cryaa:DsRed) |
| 1 | Schumacher et al., 2024 | ||
| Tg(she:actr10-2A-mRFP) |
|
| 1 | (2) | |
| Tg(she:GAP-GFP) |
|
| 1 | Denans et al., 2022 | |
| Tg(she:GCaMP6s) |
|
| 1 | (2) | |
| Tg(she:h2ax-mCherry) |
|
| 1 | Peloggia et al., 2021 | |
| Tg(she:Hsa.HIST1H2BJ-EGFP) |
|
| 1 | Peloggia et al., 2021 | |
| Tg(she:Hsa.HIST1H2BJ-mTurquoise) |
|
| 1 | Denans et al., 2022 | |
| Tg(she:lck-mScarletI) |
|
| 1 | Denans et al., 2022 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-105C13 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_684895 (1) | 5270 nt | ||
| Genomic | GenBank:BX950871 (1) | 165048 nt | ||
| Polypeptide | UniProtKB:E7F7N7 (1) | 438 aa |
- Schumacher, J.A., Wright, Z.A., Rufin Florat, D., Anand, S.K., Dasyani, M., Batta, S.P.R., Laverde, V., Ferrari, K., Klimkaite, L., Bredemeier, N.O., Gurung, S., Koller, G.M., Aguera, K.N., Chadwick, G.P., Johnson, R.D., Davis, G.E., Sumanas, S. (2024) SH2 domain protein E and ABL signaling regulate blood vessel size. PLoS Genetics. 20:e1010851e1010851
- Denans, N., Tran, N.T.T., Swall, M.E., Diaz, D.C., Blanck, J., Piotrowski, T. (2022) An anti-inflammatory activation sequence governs macrophage transcriptional dynamics during tissue injury in zebrafish. Nature communications. 13:5356
- Zhang, Q., Kindt, K.S. (2022) Using Light-Sheet Microscopy to Study Spontaneous Activity in the Developing Lateral-Line System. Frontiers in cell and developmental biology. 10:819612
- Peloggia, J., Münch, D., Meneses-Giles, P., Romero-Carvajal, A., Lush, M.E., Lawson, N.D., McClain, M., Pan, Y.A., Piotrowski, T. (2021) Adaptive cell invasion maintains lateral line organ homeostasis in response to environmental changes. Developmental Cell. 56(9):1296-1312.e7
- Moore, C., Richens, J.L., Hough, Y., Ucanok, D., Malla, S., Sang, F., Chen, Y., Elworthy, S., Wilkinson, R.N., Gering, M. (2018) Gfi1aa and Gfi1b set the pace for primitive erythroblast differentiation from hemangioblasts in the zebrafish embryo. Blood advances. 2:2589-2606
- Quillien, A., Abdalla, M., Yu, J., Ou, J., Zhu, L.J., Lawson, N.D. (2017) Robust Identification of Developmentally Active Endothelial Enhancers in Zebrafish Using FANS-Assisted ATAC-Seq. Cell Reports. 20:709-720
- Chen, J., Zhu, R.F., Li, F.F., Liang, Y.L., Wang, C., Qin, Y.W., Huang, S., Zhao, X.X., Jing, Q. (2016) MicroRNA-126a Directs Lymphangiogenesis Through Interacting With Chemokine and Flt4 Signaling in Zebrafish. Arteriosclerosis, Thrombosis, and Vascular Biology. 36(12):2381-2393
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Rost, M.S., Sumanas, S. (2014) Hyaluronic acid receptor Stabilin-2 regulates Erk phosphorylation and arterial--venous differentiation in zebrafish. PLoS One. 9:e88614
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
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