Gene

lck

ID
ZDB-GENE-040617-1
Name
LCK proto-oncogene, Src family tyrosine kinase
Symbol
lck Nomenclature History
Previous Names
  • zgc:136695
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to have non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Predicted to be involved in several processes, including T cell differentiation; cell surface receptor signaling pathway; and peptidyl-tyrosine autophosphorylation. Predicted to localize to extrinsic component of cytoplasmic side of plasma membrane. Is expressed in T cell; head kidney; lymphocyte; pro-T cell; and thymus. Human ortholog(s) of this gene implicated in immunodeficiency 22. Orthologous to human LCK (LCK proto-oncogene, Src family tyrosine kinase).
Genome Resources
Note
None
Expression
All Expression Data
31 figures from 26 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With lck Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
immunodeficiency 22 Alliance ?Immunodeficiency 22 615758
Associated With lck Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR000980 SH2 domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR001452 SH3 domain
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Domain IPR035749 Lck, SH3 domain
Domain IPR035850 Tyrosine-protein kinase Lck, SH2 domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR036028 SH3-like domain superfamily
Homologous_superfamily IPR036860 SH2 domain superfamily
Domain Details Per Protein
Protein Length Lck, SH3 domain Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain SH2 domain SH2 domain superfamily SH3 domain SH3-like domain superfamily Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase Lck, SH2 domain
UniProtKB:Q1RLY5 503
UniProtKB:Q6TPQ4 503
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations