ZFIN ID: ZDB-GENE-040426-987
Gene Name: H2A.X variant histone
Gene Symbol: h2ax    Nomenclature History

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Previous Names: H2A.X (1), h2afx, zgc:56329

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have DNA binding activity. Involved in cellular response to DNA damage stimulus. Predicted to localize to centrosome and nuclear chromatin. Is expressed in several structures, including brain; oocyte; proliferative region; sensory system; and unfertilized egg. Orthologous to human H2AX (H2A.X variant histone).
Genome Resources: Alliance (1),  Gene:394048 (1),  Ensembl(GRCz11):ENSDARG00000029406 (2)
GENE EXPRESSION
All Expression Data: 15 figures from 10 publications
Directly Submitted Expression Data: 6 figures (11 images) from Thisse et al., 2004 [MGC:56329]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH h2ax HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH h2ax VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process cellular response to DNA damage stimulus (more)
Cellular Component centrosome (more)
Molecular Function DNA binding (more)
GO Terms (all 14)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA h2afx-201 (1)    Ensembl 626
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab2-h2afx polyclonal Rabbit WB Cell Signaling Technology, Inc.
5
Ab3-h2afx polyclonal Rabbit IHC, WB Signalway Antibody Co.
3
Ab1-h2afx polyclonal IHC, WB 12
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM h2ax
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(h2ax:EGFP-rab5c) h2ax EGFPrab5c Danio rerio 1 9
Tg(h2ax:EGFP-rab7a) h2ax EGFPrab7a Danio rerio 1 9
Tg(h2ax:EGFP-rab11a) h2ax EGFPrab11a Danio rerio 1 6
Tg(h2ax:h2az2a-mCherry) h2ax h2az2amCherry Danio rerio 1 8
Tg(h2ax:prom1b-GFP) h2ax GFPprom1b Danio rerio 1 2
tg(ubb:h2ax-egfp-2a-mcherry-caax) ubb 2ACAAXEGFPh2axmCherry Danio rerio 1 1
MARKER RELATIONSHIPS
h2ax Contained in: [BAC] DKEY-151N15 (1) (order this)
h2ax Encodes: [cDNA] MGC:56329 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_201073 (1) 643 nt
Genomic GenBank:BX294169 (1) 73230 nt
Select Tool
Polypeptide UniProtKB:Q7ZUY3 (1) 142 aa
Sequence Information (all 9)
ORTHOLOGY for h2ax ( Chr: 5 )
CITATIONS (58)