Gene

fli1

ID
ZDB-GENE-980526-426
Name
Fli-1 proto-oncogene, ETS transcription factor
Symbol
fli1 Nomenclature History
Previous Names
  • fli-1
  • fli1
  • fli1a
  • fli
  • cb855 (1)
  • wu:fc45b11
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in angiogenesis and positive regulation of DNA-binding transcription factor activity. Predicted to localize to nucleus. Is expressed in several structures, including angioblastic mesenchymal cell; cardiovascular system; hematopoietic system; mesoderm; and pharyngeal arch. Human ortholog(s) of this gene implicated in blood platelet disease and thrombocytopenia. Orthologous to human FLI1 (Fli-1 proto-oncogene, ETS transcription factor).
Genome Resources
Note
This gene is orthologous to Fli-1 proto-oncogene, ETS transcription factor, but analyses indicate that the ancestral gene was duplicated prior to the divergence of ray- and lobe-fin fishes and not the result of the WGD event in the ray-fin fishes, so the gene name has been updated to fli1.
Expression
All Expression Data
187 figures from 125 publications
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Liu et al., 2008
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fli1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Bleeding disorder, platelet-type, 21 617443
Associated With fli1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000418 Ets domain
Domain IPR003118 Pointed domain
Domain IPR035573 Friend leukemia integration 1 transcription factor, pointed domain
Family IPR035575 Friend leukemia integration 1 transcription factor
Homologous_superfamily IPR013761 Sterile alpha motif/pointed domain superfamily
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Ets domain Friend leukemia integration 1 transcription factor Friend leukemia integration 1 transcription factor, pointed domain Pointed domain Sterile alpha motif/pointed domain superfamily Winged helix DNA-binding domain superfamily Winged helix-like DNA-binding domain superfamily
UniProtKB:Q1L8J0 212
UniProtKB:Q9PUL6 414
UniProtKB:Q1LUW5 265
UniProtKB:Q1L8J3 200
UniProtKB:Q1LUW4 185
UniProtKB:Q9PU61 451
UniProtKB:Q1L8J1 123
UniProtKB:A0A2R8QGN6 460
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations