Gene
mapk1
- ID
- ZDB-GENE-030722-2
- Name
- mitogen-activated protein kinase 1
- Symbol
- mapk1 Nomenclature History
- Previous Names
-
- ERK2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within gastrulation. Predicted to be located in centrosome and spindle. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including EVL; brain; cardiovascular system; retina; and superficial blastomere. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 13; Parkinson's disease; adenocarcinoma (multiple); pulmonary hypertension; and renal cell carcinoma. Orthologous to human MAPK1 (mitogen-activated protein kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56570 (10 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Noonan syndrome 13 | Alliance | Noonan syndrome 13 | 619087 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Conserved_site | IPR003527 | Mitogen-activated protein (MAP) kinase, conserved site |
| Domain | IPR000719 | Protein kinase domain |
| Family | IPR008349 | Mitogen-activated protein (MAP) kinase, ERK1/2 |
| Family | IPR050117 | Mitogen-activated protein kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Mitogen-activated protein kinase | Mitogen-activated protein (MAP) kinase, conserved site | Mitogen-activated protein (MAP) kinase, ERK1/2 | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7ZW72
|
369 |
Interactions and Pathways
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab2-mapk | monoclonal | IgG1 | Mouse |
|
Sigma-Aldrich
|
25 | |
| Ab3-mapk | polyclonal | IgG | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
9 |
Plasmids
No data available