Gene
mapk1
- ID
- ZDB-GENE-030722-2
- Name
- mitogen-activated protein kinase 1
- Symbol
- mapk1 Nomenclature History
- Previous Names
-
- ERK2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have MAP kinase activity. Involved in gastrulation. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in adenocarcinoma (multiple); pulmonary hypertension; and renal cell carcinoma. Is expressed in several structures, including EVL; brain; cardiovascular system; retina; and superficial blastomere. Orthologous to human MAPK1 (mitogen-activated protein kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56570 (10 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Noonan syndrome 13 | Alliance | Noonan syndrome 13 | 619087 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Conserved_site | IPR003527 | Mitogen-activated protein (MAP) kinase, conserved site |
| Domain | IPR000719 | Protein kinase domain |
| Family | IPR008349 | Mitogen-activated protein (MAP) kinase, ERK1/2 |
| Family | IPR050117 | Mitogen-activated protein kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Mitogen-activated protein kinase | Mitogen-activated protein (MAP) kinase, conserved site | Mitogen-activated protein (MAP) kinase, ERK1/2 | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7ZW72
|
369 |
Interactions and Pathways
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab2-mapk | monoclonal | IgG1 | Mouse |
|
Sigma-Aldrich
|
25 | |
| Ab3-mapk | polyclonal | IgG | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
9 |
Plasmids
No data available