ZFIN ID: ZDB-GENE-030722-2
Gene Name: mitogen-activated protein kinase 1
Gene Symbol: mapk1    Nomenclature History

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Previous Name: ERK2 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have MAP kinase activity. Involved in gastrulation. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in adenocarcinoma (multiple); pulmonary hypertension; and renal cell carcinoma. Is expressed in several structures, including EVL; brain; cardiovascular system; retina; and superficial blastomere. Orthologous to human MAPK1 (mitogen-activated protein kinase 1).
Genome Resources: Alliance (1),  Gene:360144 (1),  Ensembl(GRCz11):ENSDARG00000027552 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa33546 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33547 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-mapk1 N/A 3
    DISEASE ASSOCIATED WITH mapk1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH mapk1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process gastrulation (more)
    Cellular Component cytoplasm (more)
    Molecular Function ATP binding (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript mapk1-204 (1)    Ensembl 607
    mRNA mapk1-201 (1)    Ensembl 1641
    mapk1-203 (1)    Ensembl 1411
    ncRNA mapk1-003 (1)    Ensembl 904
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab2-mapk monoclonal IgG1 Mouse IHC, WB Sigma-Aldrich
    19
    Ab3-mapk polyclonal IgG Rabbit WB Santa Cruz Biotechnology, Inc.
    8
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mapk1 No data available
    MARKER RELATIONSHIPS
    mapk1 Contained in: [BAC] DKEY-72G15 (1) (order this)
    mapk1 Encodes: [cDNA] MGC:56570 (1), MGC:77792 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_182888 (1) 1651 nt
    Genomic GenBank:BX005237 (1) 213290 nt Blast at MegaBLAST
    Polypeptide UniProtKB:Q4VH14 (1) 369 aa
    Sequence Information (all 20)
    ORTHOLOGY for mapk1 ( Chr: 5 )
    CITATIONS (51)